School of Chemistry and Biological Engineering, University of Science and Technology Beijing, Beijing, China.
Daxing Research Institute, University of Science and Technology Beijing, Beijing, China.
Diabetes Metab Res Rev. 2023 May;39(4):e3638. doi: 10.1002/dmrr.3638. Epub 2023 Apr 8.
The delayed healing of diabetic wounds (DBW) will not only afflict patients, but also lead to amputation and even death in serious cases, which will create many negative effects on society and the country. Mesenchymal stromal cells (MSCs) have attracted extensive attention for their applications in chronic wound healing due to their excellent cytokine secretion ability and regulation of inflammation. Mesenchymal stromal cells can be used alone or wrapped with carrier/matrix and applied to enhance healing in the wound area. In this review, the etiology of the slow healing of DBW and the mechanism by which MSCs promote the healing of DBW were explored. In addition, we summarised the current research progress on the use of stromal cell-loaded biomaterials for wound healing in diabetic animal models. At the end of the article, we pointed out the challenges and improvement strategies for stromal cell therapy applied to DBW in future clinical practice.
糖尿病创面（DBW）的延迟愈合不仅会折磨患者，严重情况下还会导致截肢甚至死亡，这将给社会和国家带来许多负面影响。间充质基质细胞（MSCs）因其出色的细胞因子分泌能力和对炎症的调节作用，在慢性创面愈合方面的应用引起了广泛关注。MSCs 可以单独使用，也可以与载体/基质一起包裹并应用于创面区域以增强愈合。在这篇综述中，我们探讨了 DBW 愈合缓慢的病因以及 MSCs 促进 DBW 愈合的机制。此外，我们总结了目前关于使用负载基质细胞的生物材料治疗糖尿病动物模型创面愈合的研究进展。文章最后，我们指出了未来临床应用基质细胞治疗 DBW 所面临的挑战和改进策略。
