Health Impacts of Long-Term NO Exposure and Inequalities among the Chinese Population from 2013 to 2020.

Nitrogen dioxide (NO) is associated with mortality and many other adverse health outcomes. In 2021, the World Health Organization established a new NO air quality guideline (AQG) (annual average <10 μg/m). However, the burden of diseases attributable to long-term NO exposure above the AQG is unknown in China. Nitrogen oxide is a major air pollutant in populous cities, which are disproportionately impacted by NO; this represents a form of environmental inequality. We conducted a nationwide risk assessment of premature deaths attributable to long-term NO exposure from 2013 to 2020 based on the exposure-response relationship, high-resolution annual NO concentrations, and gridded population data (considering sex, age, and residence [urban vs rural]). We calculated health metrics including attributable deaths, years of life lost (YLL), and loss of life expectancy (LLE). Inequality in the distribution of attributable deaths and YLLs was evaluated by the Lorenz curve and Gini index. According to the health impact assessments, in 2013, long-term NO exposure contributed to 315,847 (95% confidence interval [CI]: 306,709-319,269) premature deaths, 7.90 (7.68-7.99) million YLLs, and an LLE of 0.51 (0.50-0.52) years. The high-risk subgroup (top 20%) accounted for 85.7% of all NO-related deaths and 85.2% of YLLs, resulting in Gini index values of 0.81 and 0.67, respectively. From 2013 to 2020, the estimated health impact from NO exposure was significantly reduced, but inequality displayed a slightly increasing trend. Our study revealed a considerable burden of NO-related deaths in China, which were disproportionally frequent in a small high-risk subgroup. Future clean air initiatives should focus not only on reducing the average level of NO exposure but also minimizing inequality.