Department of Radiology, Dokuz Eylül University Faculty of Medicine, İzmir, Turkey.
Diagn Interv Radiol. 2023 Jan 31;29(1):59-67. doi: 10.4274/dir.2022.221363. Epub 2023 Jan 12.
Metaplastic breast cancer (MBC) is a rare subtype of invasive breast cancer characterized by mixed epithelial and mesenchymal differentiation. Commonly seen subtypes include squamous cell carcinoma, spindle cell carcinoma, and metaplastic carcinoma with heterologous mesenchymal differentiation. MBC tends to have a more aggressive clinical presentation, higher metastatic potential, higher rates of local recurrence, and a worse prognosis compared with invasive breast carcinoma of no special type. Most MBCs are triple-negative breast cancers, which explains their resistance to most systemic therapies. Therefore, accurately diagnosing MBC early is crucial for deciding the treatment strategy and predicting the prognosis. In this pictorial essay, the imaging findings of MBC in different modalities and the histopathologic features of its subtypes are reviewed.
化生性乳腺癌（MBC）是一种罕见的浸润性乳腺癌亚型，其特征为上皮和间叶混合分化。常见的亚型包括鳞状细胞癌、梭形细胞癌和伴有异源间叶分化的化生性癌。与非特殊型浸润性乳腺癌相比，MBC 具有更具侵袭性的临床表现、更高的转移潜能、更高的局部复发率和更差的预后。大多数 MBC 是三阴性乳腺癌，这解释了它们对大多数全身治疗的耐药性。因此，早期准确诊断 MBC 对于确定治疗策略和预测预后至关重要。在本影像学专题论文中，回顾了 MBC 在不同影像学模式下的影像学表现及其各亚型的组织病理学特征。
