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急性脑出血中动脉二氧化碳的重症监护管理:对脑血流动力学影响的病例报告

Intensive care management of arterial carbon dioxide in acute intracerebral haemorrhage: Case report of influences on cerebral haemodynamics.

作者信息

Caldas Juliana R, Passos Rogério da H, Robinson Thompson G, Panerai Ronney B, Minhas Jatinder S

机构信息

Escola Bahiana de Medicina e Saúde Pública, Universidade de Salvador, UNIFACS, Critical Care Unit, Hospital São Rafael Salvador, Salvador, Brazil.

Critical Care Unit, Hospital São Rafael Salvador, Salvador, Brazil.

出版信息

Ultrasound. 2020 Nov;28(4):260-265. doi: 10.1177/1742271X20903753. Epub 2020 Feb 5.

DOI:10.1177/1742271X20903753
PMID:36959898
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10028384/
Abstract

Intracerebral haemorrhage is relatively common and has devastating consequences. Furthermore, non-invasive and invasive strategies to manage raised intracranial pressure remain limited and associated with high morbidity and mortality. We report a case of a 72-year-old male with intracerebral haemorrhage with ventricular extension, hydrocephalus and intracranial hypertension, who was evaluated by transcranial Doppler ultrasound and optic nerve sheath diameter. This case demonstrates that beyond pharmacological and surgical interventions, simple manipulation of arterial carbon dioxide has the propensity to improve cerebral haemodynamic parameters. Our results demonstrate the negative effects of hypercapnia on cerebral autoregulation and the benefits of having transcranial Doppler ultrasound available in the intensive care unit point of care.

摘要

脑出血相对常见且后果严重。此外,用于控制颅内压升高的非侵入性和侵入性策略仍然有限,且与高发病率和死亡率相关。我们报告了一例72岁男性脑出血病例,伴有脑室扩展、脑积水和颅内高压,该患者接受了经颅多普勒超声和视神经鞘直径评估。该病例表明,除了药物和手术干预外,简单地调节动脉二氧化碳水平有改善脑血流动力学参数的倾向。我们的结果证明了高碳酸血症对脑自动调节的负面影响,以及在重症监护病房即时护理中使用经颅多普勒超声的益处。

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Blood pressure control and clinical outcomes in acute intracerebral haemorrhage: a preplanned pooled analysis of individual participant data.血压控制与急性脑出血的临床结局:一项个体化参与者数据的预先计划的 pooled 分析。
Lancet Neurol. 2019 Sep;18(9):857-864. doi: 10.1016/S1474-4422(19)30196-6.
2
Brain ultrasonography: methodology, basic and advanced principles and clinical applications. A narrative review.脑超声检查:方法学、基础与高级原理及临床应用。一篇叙述性综述。
Intensive Care Med. 2019 Jul;45(7):913-927. doi: 10.1007/s00134-019-05610-4. Epub 2019 Apr 25.
3
Intravenous administration of Milrinone, as an alternative approach to treat vasospasm in subarachnoid hemorrhage: A case report of transcranial Doppler monitoring.静脉注射米力农作为治疗蛛网膜下腔出血血管痉挛的替代方法:经颅多普勒监测病例报告
Clin Case Rep. 2019 Feb 19;7(4):648-652. doi: 10.1002/ccr3.2034. eCollection 2019 Apr.
4
Dynamic cerebral autoregulation: A marker of post-operative delirium?动态脑自动调节:术后谵妄的标志物?
Clin Neurophysiol. 2019 Jan;130(1):101-108. doi: 10.1016/j.clinph.2018.11.008. Epub 2018 Nov 22.
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Impaired cerebral autoregulation and neurovascular coupling in middle cerebral artery stroke: Influence of severity?大脑中动脉卒中患者脑自动调节和神经血管耦合功能受损:严重程度的影响?
J Cereb Blood Flow Metab. 2019 Nov;39(11):2277-2285. doi: 10.1177/0271678X18794835. Epub 2018 Aug 17.
6
Optic nerve sheath diameter measured sonographically as non-invasive estimator of intracranial pressure: a systematic review and meta-analysis.超声测量视神经鞘直径作为颅内压无创估计指标的系统评价和荟萃分析。
Intensive Care Med. 2018 Aug;44(8):1284-1294. doi: 10.1007/s00134-018-5305-7. Epub 2018 Jul 17.
7
Feasibility of Improving Cerebral Autoregulation in Acute Intracerebral Haemorrhage (BREATHE-ICH) study: a protocol for an experimental interventional study.改善急性脑出血患者脑自动调节功能的可行性(BREATHE-ICH)研究:一项实验性干预研究方案
BMJ Open. 2018 Mar 27;8(3):e020758. doi: 10.1136/bmjopen-2017-020758.
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Neurology. 2017 May 23;88(21):2043-2051. doi: 10.1212/WNL.0000000000003952. Epub 2017 Apr 26.
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Physiol Meas. 2016 May;37(5):673-82. doi: 10.1088/0967-3334/37/5/673. Epub 2016 Apr 19.
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Transfer function analysis of dynamic cerebral autoregulation: A white paper from the International Cerebral Autoregulation Research Network.动态脑自动调节的传递函数分析:国际脑自动调节研究网络白皮书
J Cereb Blood Flow Metab. 2016 Apr;36(4):665-80. doi: 10.1177/0271678X15626425. Epub 2016 Jan 18.