Zare Karizak Sara, Kashef Majid, Gaeini Abbas Ali, Nejatian Mostafa
Sport Science Department, Faculty of Literature and Humanities, Persian Gulf University, Boushehr, Iran.
Exercise Physiology Department, Sport Science Faculty, Shahid Rajaee Teacher Training University, Tehran, Iran.
Front Physiol. 2023 Mar 7;14:1114813. doi: 10.3389/fphys.2023.1114813. eCollection 2023.
ProBNP/BNP, and NT-pro-BNP/BNP ratios are significant indices for predicting complications after coronary artery bypass grafting (CABG) surgery. However, the effect of aerobic training types on these biomarkers has not been fully understood. So, the current study aimed to determine the impact of aerobic interval and continuous training programs on plasma ratios of ProBNP/BNP and NT-pro-BNP/BNP after coronary artery bypass grafting surgery. 36 patients were selected purposive (27 men and 9 women with mean of age 60.32 ± 5.81 years, height 164.64 ± 9.25 cm, weight 73.86 ± 14.23 kg, fat 32.30 ± 4.28, SBP 142.67 ± 6.49, DBP 84.5 ± 5.16 mmHg in seated position at rest situation and functional capacity of 7.08 ± 2.49 METs) and then divided randomly into three groups: control (C) group (without training program) moderate continuous training (MCT) and high intensity interval training (HIIT) (exercise training program was performed 3 days/week for 8 weeks) with intensities 65%-80% and 80%-95% of reserve heart rate in order. Blood samples were taken 48 h before the first session and 48 h after the last training session to measure the plasma levels of ProBNP, corin enzyme, BNP, and NT-pro-BNP using the enzyme-linked immunosorbent assay (ELISA) technique. Wilcoxin and kruskal wallis tests were used for analyzing data. The plasma corin enzyme was increased, and the ratios of proBNP/BNP and NT-pro-BNP/BNP were reduced in both training groups in compared with control group ( = 0.004, = 0000, = 0.016, = 0.003, = 0.009, and = 0.016) when there was no significant difference was found between training groups ( = 0.074, = 450, and = 0.295). Both high intensity interval training and moderate continuous training in compared with inactivity have positive effects on ratios of ProBNP/BNP, NT-pro-BNP/BNP and could be effective to promote the health of coronary arteries and prevention of HF in post-CABG patients.
脑钠肽前体/脑钠肽（ProBNP/BNP）以及N末端B型利钠肽原/脑钠肽（NT-pro-BNP/BNP）比值是预测冠状动脉旁路移植术（CABG）后并发症的重要指标。然而，有氧训练类型对这些生物标志物的影响尚未完全明确。因此，本研究旨在确定有氧间歇训练和持续训练方案对冠状动脉旁路移植术后血浆ProBNP/BNP和NT-pro-BNP/BNP比值的影响。选取36例患者（27例男性和9例女性，平均年龄60.32±5.81岁，身高164.64±9.25cm，体重73.86±14.23kg，体脂32.30±4.28，静息坐位时收缩压142.67±6.49，舒张压84.5±5.16mmHg，功能能力7.08±2.49代谢当量），然后随机分为三组：对照组（C组，无训练方案）、中等强度持续训练（MCT）组和高强度间歇训练（HIIT）组（运动训练方案为每周3天，共8周），强度依次为储备心率的65%-80%和80%-95%。在第一次训练前48小时和最后一次训练后48小时采集血样，采用酶联免疫吸附测定（ELISA）技术检测血浆ProBNP、corin酶、BNP和NT-pro-BNP水平。使用Wilcoxin和kruskal wallis检验分析数据。与对照组相比，两个训练组的血浆corin酶升高，proBNP/BNP和NT-pro-BNP/BNP比值降低（P=0.004，P=0.000，P=0.016，P=0.003，P=0.009，P=0.016），而训练组之间无显著差异（P=0.074，P=0.450，P=0.295）。与不运动相比，高强度间歇训练和中等强度持续训练对ProBNP/BNP、NT-pro-BNP/BNP比值均有积极影响，可能有助于促进冠状动脉旁路移植术后患者的冠状动脉健康和预防心力衰竭。
