Chisolm J C, Handorf C R
Dept. of Obstetrics, Methodist Hospital, Memphis, Tennessee 38104.
Med Hypotheses. 1987 Dec;24(4):347-51. doi: 10.1016/0306-9877(87)90212-x.
Laboratory animals have a unique sensitivity to cadmium toxicity in late pregnancy. This acute toxicity is not seen in non-pregnant, early pregnant, or lactating animals. Furthermore, during late pregnancy, laboratory animals absorb and retain substantially more cadmium from their diets than they do in the non-pregnant state. Both of these observations parallel the fact that a fivefold late gestational drop of maternal metallothionein (a metal-binding protein believed to detoxify cadmium) has been demonstrated in pregnant animals. Additional factors such as nutritional status and age affect cadmium absorption. As we have discussed previously, cadmium toxicity and toxemia of pregnancy have many common features including hypertension, proteinuria, edema, vasospasm and endovasculitis. Because of the above, we propose that cadmium plays a role in the etiology of toxemia.
实验动物在妊娠晚期对镉毒性具有独特的敏感性。这种急性毒性在未怀孕、怀孕早期或哺乳期的动物中未见。此外，在妊娠晚期，实验动物从饮食中吸收和保留的镉比处于非妊娠状态时要多得多。这两个观察结果都与以下事实相符：已证实在怀孕动物中，母体金属硫蛋白（一种被认为可使镉解毒的金属结合蛋白）在妊娠晚期下降了五倍。营养状况和年龄等其他因素会影响镉的吸收。正如我们之前所讨论的，镉毒性和妊娠毒血症有许多共同特征，包括高血压、蛋白尿、水肿、血管痉挛和血管内炎症。基于上述原因，我们认为镉在妊娠毒血症的病因中起作用。
