Chisolm J C, Handorf C R
Department of Obstetrics, Methodist Hospitals of Memphis, Tennessee 38104, USA.
Med Hypotheses. 1996 Aug;47(2):123-8. doi: 10.1016/s0306-9877(96)90451-x.
Cadmium-metallothionein, mobilized from the liver, might be the toxic serum factor associated with pre-eclampsia. We base this on four documented concepts. First, during pregnancy, maternal physiology adjusts to assure the fetus of the proper amounts of nutrients necessary for growth. Our focus is on zinc and progesterone. Second, because zinc and cadmium are similar, they compete for binding sites. Our focus is on the storage protein metallothionein. Third, the manifestations of cadmium toxicity closely mimic the manifestations of toxemia (i.e. hypertension, proteinuria, edema). Our focus is on cadmium-induced endovasculitis. Fourth is the concept that metallothionein-bound cadmium can be mobilized from the liver into the serum during pregnancy as it follows the mobilization of metallothionein-bound zinc. Our focus is on the extreme toxicity of extracellular cadmium-metallothionein. We correlate these four concepts into a rational theory on the etiology of toxemia, and we suggest a method of proof.
从肝脏中释放出来的镉-金属硫蛋白可能是与先兆子痫相关的有毒血清因子。我们基于四个有文献记载的概念得出这一结论。首先，在怀孕期间，母体生理机能会进行调整，以确保胎儿获得生长所需的适量营养物质。我们关注的是锌和孕酮。其次，由于锌和镉相似，它们会竞争结合位点。我们关注的是储存蛋白金属硫蛋白。第三，镉中毒的表现与毒血症的表现极为相似（即高血压、蛋白尿、水肿）。我们关注的是镉诱导的血管内炎症。第四是这样一个概念，即与金属硫蛋白结合的镉在怀孕期间会随着与金属硫蛋白结合的锌的动员而从肝脏转移到血清中。我们关注的是细胞外镉-金属硫蛋白的极高毒性。我们将这四个概念关联成一个关于毒血症病因的合理理论，并提出了一种验证方法。
