比较伴有和不伴有炎症性肠病的偏头痛患者的特征：一项回顾性队列研究。

Comparison of Migraine Characteristics in Patients With and Without Inflammatory Bowel Disease: A Retrospective Cohort Study.

机构信息

Mayo Clinic Florida, Jacksonville, FL, USA.

出版信息

J Prim Care Community Health. 2023 Jan-Dec;14:21501319231164307. doi: 10.1177/21501319231164307.

DOI:10.1177/21501319231164307

PMID:36960555

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10041579/

Abstract

BACKGROUND

Survey studies have found an increased prevalence of migraine in patients with inﬂammatory bowel disease (IBD). However, the clinical characteristics of migraines in this population are unknown. We conducted a retrospective medical record review study to characterize migraines in the IBD population.

METHODS

Six hundred seventy-five migraine patients (280 with IBD, 395 without IBD) who were evaluated at Mayo Clinic Rochester, Mayo Clinic Arizona, or Mayo Clinic Florida between July 2009 and March 2021 were included. Patients with ICD codes for migraine and either Crohn's disease (CD) or ulcerative colitis (UC) were selected. Electronic health care records were reviewed. Patients conﬁrmed to have IBD and migraine were included. Demographic, IBD, and migraine characteristics were collected. Statistical analysis was completed using SAS.

RESULTS

Patients with IBD were less often male (8.6% vs 21.3%, P < .001) and had a higher Charlson Comorbidity Index (>2: 24.6% vs 15.7%, P = .003); 54.6% had CD and 39.3% had UC. Patients with IBD had migraine with aura and without aura more frequently ( OR 2.20, P < .001 and OR 2.79, P < .001, respectively) than non-IBD patients. Additionally, those with IBD less commonly had chronic migraine (OR 0.23, P < .001) and less commonly had chronic migraine or treatment for migraine (ORs 0.23-0.55, P ≤ .002).

CONCLUSIONS

Migraine with and without aura have increased prevalence in IBD patients. Further study of this topic will be helpful to clarify the prevalence of migraine, establish this population's response to treatment, and better understand the reason(s) for a low rate of treatment.

摘要

背景

调查研究发现，炎症性肠病（IBD）患者偏头痛的患病率增加。然而，目前尚不清楚该人群偏头痛的临床特征。我们进行了一项回顾性病历回顾研究，以描述 IBD 人群中的偏头痛。

方法

纳入 2009 年 7 月至 2021 年 3 月在梅奥诊所罗切斯特院区、梅奥诊所亚利桑那院区或梅奥诊所佛罗里达院区就诊的 675 例偏头痛患者（280 例 IBD 患者，395 例非 IBD 患者）。选择具有偏头痛 ICD 编码和克罗恩病（CD）或溃疡性结肠炎（UC）的患者。回顾电子医疗记录。纳入确诊 IBD 和偏头痛的患者。收集人口统计学、IBD 和偏头痛特征。使用 SAS 完成统计分析。

结果

IBD 患者中男性较少（8.6%比 21.3%，P < .001），Charlson 合并症指数较高（>2：24.6%比 15.7%，P = .003）；54.6%的患者患有 CD，39.3%的患者患有 UC。IBD 患者偏头痛伴先兆和不伴先兆的发病率更高（OR 2.20，P < .001 和 OR 2.79，P < .001）。此外，IBD 患者慢性偏头痛的发病率较低（OR 0.23，P < .001），慢性偏头痛或偏头痛治疗的发病率也较低（OR 0.23-0.55，P ≤ .002）。