银屑病关节炎和轴性脊柱关节炎患者头痛和偏头痛患病率增加：一项意大利队列研究的见解
Increased Prevalence of Headaches and Migraine in Patients with Psoriatic Arthritis and Axial Spondyloarthritis: Insights from an Italian Cohort Study.
作者信息
Marino Annalisa, Currado Damiano, Altamura Claudia, Vomero Marta, Berardicurti Onorina, Corberi Erika, Kun Lyubomyra, Pilato Andrea, Biaggi Alice, Genovali Irene, Bearzi Pietro, Minerba Marco, Orlando Antonio, Trunfio Francesca, Quadrini Maria, Salvolini Chiara, Di Corcia Letizia Pia, Saracino Francesca, Giacomelli Roberto, Navarini Luca
机构信息
Rheumatology and Clinical Immunology, Department of Medicine, School of Medicine, University of Rome "Campus Bio-Medico", 00128 Rome, Italy.
Clinical and Research Section of Rheumatology and Clinical Immunology, Fondazione Policlinico Universitario Campus Bio-Medico, 00128 Rome, Italy.
出版信息
Biomedicines. 2024 Feb 5;12(2):371. doi: 10.3390/biomedicines12020371.
BACKGROUND
Psoriatic arthritis (PsA) and axial spondyloarthritis (axSpA) are inflammatory diseases with shared genetic backgrounds and clinical comorbidities. Headache, a common global health issue, affects over 50% of adults and encompasses various types, including migraine, tension-type, and cluster headaches. Migraine, the most prevalent, recurrent, and disabling type, is often associated with other medical conditions such as depression, epilepsy, and psoriasis, but little is known about the relationship between autoimmune disease and the risk of migraine.
METHODS
A cross-sectional study was conducted from July to November 2022, enrolling 286 participants, including 216 with PsA, 70 with axSpA, and 87 healthy controls.
RESULTS
Headache prevalence was significantly higher in the PsA (39.81%) and axSpA (45.71%) patients compared to the healthy controls. The prevalence of migraine without aura was also significantly higher in both the PsA (18.52%) and axSpA (28.57%) groups compared to the healthy controls.
CONCLUSIONS
These findings underscore the high burden of headache and migraine in PsA and axSpA participants, highlighting the need for improved management and treatment strategies for these patients.
背景
银屑病关节炎（PsA）和轴性脊柱关节炎（axSpA）是具有共同遗传背景和临床合并症的炎症性疾病。头痛是一个常见的全球健康问题，影响超过50%的成年人，包括多种类型，如偏头痛、紧张型头痛和丛集性头痛。偏头痛是最常见、复发性和致残性的类型，通常与其他疾病如抑郁症、癫痫和银屑病有关，但关于自身免疫性疾病与偏头痛风险之间的关系知之甚少。
方法
于2022年7月至11月进行了一项横断面研究，招募了286名参与者，包括216名银屑病关节炎患者、70名轴性脊柱关节炎患者和87名健康对照者。
结果
与健康对照者相比，银屑病关节炎患者（39.81%）和轴性脊柱关节炎患者（45.71%）的头痛患病率显著更高。与健康对照者相比，无先兆偏头痛的患病率在银屑病关节炎组（18.52%）和轴性脊柱关节炎组（28.57%）中也显著更高。
结论
这些发现强调了银屑病关节炎和轴性脊柱关节炎患者中头痛和偏头痛的高负担，突出了对这些患者改进管理和治疗策略的必要性。
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