Center for Cell Structure and Function, Shandong Provincial Key Laboratory of Animal Resistance Biology, Collaborative Innovation Center of Cell Biology in Universities of Shandong, College of Life Sciences, Shandong Normal University, Jinan, China.
J Cell Physiol. 2023 Jun;238(6):1141-1147. doi: 10.1002/jcp.31011. Epub 2023 Apr 6.
The microtubule cytoskeleton plays a critical role in a variety of cellular activities, and its structures and functions have been extensively studied. However, little is known about cell differentiation-related microtubule remodeling, its regulatory mechanisms, and its physiological functions. Recent studies have shown that microtubule-binding proteins as well as cell junctions, such as desmosomes and adherens junctions, are involved in the remodeling of microtubules in response to cell differentiation. In addition, the microtubule-organizing activity and structural integrity of centrosomes undergo dramatic changes during cell differentiation to promote microtubule remodeling. Here we summarize recent advances revealing the dynamic changes in microtubule organization and functions during cell differentiation. We also highlight the molecular mechanisms underlying microtubule modeling in differentiated cells, focusing on the key roles played by microtubule-binding proteins, cell junctions, and centrosomes.
微管细胞骨架在各种细胞活动中起着关键作用，其结构和功能已得到广泛研究。然而，细胞分化相关的微管重塑、其调控机制及其生理功能知之甚少。最近的研究表明，微管结合蛋白以及细胞连接，如桥粒和黏着连接，参与了微管在细胞分化时的重塑。此外，中心体的微管组织活性和结构完整性在细胞分化过程中发生剧烈变化，以促进微管重塑。在这里，我们总结了最近的进展，揭示了细胞分化过程中微管组织和功能的动态变化。我们还强调了分化细胞中微管建模的分子机制，重点介绍了微管结合蛋白、细胞连接和中心体所起的关键作用。
