Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Korea.
Department of Pathology, Chonnam National University Medical School, Gwangju, Korea.
Korean J Gastroenterol. 2023 Mar 25;81(3):129-132. doi: 10.4166/kjg.2022.128.
Primary mucosa-associated with a lymphoid tissue (MALT) lymphoma is a rare distinct subtype of non-Hodgkin's lymphoma that occurs in approximately 8% of all non-Hodgkin lymphomas. Primary gastrointestinal MALT lymphoma usually occurs in the stomach, but duodenal involvement is extremely rare. Therefore, the clinical manifestations, treatment, and prognosis of primary duodenal MALT lymphoma have not yet been validated because of its rarity. This paper reports a case of a 40-year-old male with primary duodenal MALT lymphoma who was treated successfully with radiation therapy alone. A 40-year-old male visited for a medical check-up. Esophagogastroduodenoscopy revealed whitish multi-nodular mucosal lesions in the second and third portions of the duodenum. Biopsy specimens from mucosal lesions in the duodenum were reported to be suspicious for MALT lymphoma of the duodenum. He received a total dose of 3,000 cGy in 15 fractions with external beam radiation therapy for three weeks. Three months after radiation therapy, an endoscopic examination revealed complete resolution of the duodenal lesions. The follow-up 12 months after radiation therapy showed no evidence of tumor recurrence.
原发性黏膜相关淋巴组织（MALT）淋巴瘤是一种罕见的非霍奇金淋巴瘤的独特亚型，约占所有非霍奇金淋巴瘤的 8%。原发性胃肠道 MALT 淋巴瘤通常发生在胃，但十二指肠受累极为罕见。因此，由于其罕见性，原发性十二指肠 MALT 淋巴瘤的临床表现、治疗和预后尚未得到验证。本文报告了一例成功接受单纯放射治疗的原发性十二指肠 MALT 淋巴瘤 40 岁男性患者。一名 40 岁男性因健康检查就诊。食管胃十二指肠镜检查显示十二指肠第二和第三部分有白色多结节黏膜病变。十二指肠黏膜病变的活检标本报告为疑似十二指肠 MALT 淋巴瘤。他接受了为期三周的总剂量为 3000cGy 的 15 次分次外照射放射治疗。放射治疗后三个月，内镜检查显示十二指肠病变完全缓解。放射治疗后 12 个月的随访未发现肿瘤复发的证据。
