School of Chemical Engineering and Technology, China University of Mining and Technology, Xuzhou, Jiangsu 221116, P. R. China.
Cixi Institute of Biomedical Engineering, International Cooperation Base of Biomedical Materials Technology and Application, Chinese Academy of Science (CAS) Key Laboratory of Magnetic Materials and Devices, Zhejiang Engineering Research Center for Biomedical Materials, Ningbo Institute of Materials Technology and Engineering, CAS, Ningbo 315201, P. R. China.
J Mater Chem B. 2023 Apr 12;11(15):3295-3306. doi: 10.1039/d3tb00268c.
Metal ions widely exist in biological systems and participate in many vital biochemical processes. Monitoring and analyzing metal ions in biological systems can help reveal physiological processes and understand disease causes. There are various detection methods for metal ions, among which organic small-molecule fluorescent probes have significant advantages, such as high fluorescence quantum yield, easy modification, good biocompatibility, high sensitivity, and fast real-time detection. This review presents recent studies on fluorescent probes for alkali and alkaline earth metal ions (including Na, K, Ca, and Mg) in biological systems. All the candidates are organized according to their structures, and the sensing mechanisms of fluorescent probes are also highly taken into account. Finally, the challenges, trends and prospects of fluorescent probes in metal ion detection are discussed. We hope that this review can provide guidance for the development of fluorescent molecular probe-based alkali and alkaline earth metal ion detection methods in the future.
金属离子广泛存在于生物体系中，并参与许多重要的生化过程。监测和分析生物体系中的金属离子有助于揭示生理过程和了解疾病的起因。针对金属离子，存在多种检测方法，其中有机小分子荧光探针具有显著优势，如高荧光量子产率、易于修饰、良好的生物相容性、高灵敏度以及快速实时检测。本文综述了近年来生物体系中用于检测碱金属和碱土金属离子（包括 Na、K、Ca 和 Mg）的荧光探针的研究进展。所有候选物均根据其结构进行组织，同时还高度考虑了荧光探针的传感机制。最后，讨论了荧光探针在金属离子检测方面的挑战、趋势和前景。我们希望本综述能为未来基于荧光分子探针的碱金属和碱土金属离子检测方法的发展提供指导。
