Biomedical Sciences Research Institute, University of Ulster, Coleraine, Northern Ireland, BT52 1SA, UK.
Chem Soc Rev. 2015 Jul 7;44(13):4415-32. doi: 10.1039/c4cs00365a. Epub 2015 Mar 6.
Luminescent sensors and switches continue to play a key role in shaping our understanding of key biochemical processes, assist in the diagnosis of disease and contribute to the design of new drugs and therapies. Similarly, their contribution to the environment cannot be understated as they offer a portable means to undertake field testing for hazardous chemicals and pollutants such as heavy metals. From a physiological perspective, the Group I and II metal ions are among the most important in the periodic table with blood plasma levels of H(+), Na(+) and Ca(2+) being indicators of several possible disease states. In this review, we examine the progress that has been made in the development of luminescent probes for Group I and Group II ions as well as protons. The potential applications of these probes and the mechanism involved in controlling their luminescent response upon analyte binding will also be discussed.
发光传感器和开关在深入了解关键生化过程、协助疾病诊断以及设计新药和疗法方面继续发挥着关键作用。同样，它们对环境的贡献也不可低估，因为它们为现场测试有害物质和污染物（如重金属）提供了一种便携式手段。从生理学角度来看，第 I 组和第 II 组金属离子是周期表中最重要的离子之一，血浆中 H(+)、Na(+)和 Ca(2+)的水平是几种可能疾病状态的指标。在这篇综述中，我们检查了开发用于第 I 组和第 II 组离子以及质子的发光探针方面所取得的进展。还将讨论这些探针的潜在应用以及控制它们在分析物结合时发光响应的机制。
