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[已撤回] 微小RNA-21通过激活Sox2和β-连环蛋白信号通路促进胶质瘤细胞的迁移和侵袭。

[Retracted] MicroRNA‑21 promotes migration and invasion of glioma cells via activation of Sox2 and β‑catenin signaling.

作者信息

Luo Guoxuan, Luo Wentao, Sun Xiaohui, Lin Jinzhi, Wang Mo, Zhang Yang, Luo Weishi, Zhang Yong

机构信息

Department of Neurosurgery, Guangdong No. 2 Provincial People's Hospital, Guangzhou, Guangdong 510317, P.R. China.

出版信息

Mol Med Rep. 2023 May;27(5). doi: 10.3892/mmr.2023.12982. Epub 2023 Mar 24.

DOI:10.3892/mmr.2023.12982
PMID:36960862
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10071291/
Abstract

Following the publication of the above paper, a concerned reader drew to the Editor's attention that there were several data panels showing the results of Transwell migration and invasion assay experiments in Figs. 1A and 2A that contained overlapping sections of data, such that these data, which were intended to have shown the results from differently performed experiments, appeared to have been derived from a smaller number of original sources. Furthermore, the data panels shown in Fig. 3A for the 'Control/U343' and 'Control/172', and the 'miR‑21/β‑catenin' and 'Control/T98', experiments were also found to be unexpectedly similar, given that these were likewise intended to show the results from differently performed experiments. After having conducted an independent investigation in the Editorial Office, the Editor of has determined that the above paper should be retracted from the Journal on account of a lack of confidence in the presented data. The authors were asked for an explanation to account for these concerns, but the Editorial Office did not receive a satisfactory reply. The Editor regrets any inconvenience that has been caused to the readership of the Journal. [Molecular Medicine Reports 15: 187‑193, 2017; DOI: 10.3892/mmr.2016.5971].

摘要

上述论文发表后,一位关注此事的读者提请编辑注意,在图1A和2A中有几个数据面板展示了Transwell迁移和侵袭试验实验的结果,其中包含重叠的数据部分,以至于这些本应展示不同实验结果的数据,似乎来自较少数量的原始来源。此外,图3A中显示的“对照/U343”和“对照/172”以及“miR-21/β-连环蛋白”和“对照/T98”实验的数据面板也被发现意外地相似,因为这些同样本应展示不同实验的结果。编辑部进行独立调查后,《》的编辑决定,鉴于对所呈现数据缺乏信心,上述论文应从该期刊撤回。已要求作者对这些问题作出解释,但编辑部未收到令人满意的答复。编辑对给期刊读者带来的任何不便表示歉意。[《分子医学报告》15: 187 - 193, 2017; DOI: 10.3892/mmr.2016.5971]

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