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耳真菌病的微生物结构:抗真菌药物的敏感性分析。

THE MICROBIOLOGICAL STRUCTURE OF OTOMYCOSIS: SENSITIVITY PROFILE OF AGENTS TO ANTIFUNGAL DRUGS.

机构信息

SUMY STATE UNIVERSITY, SUMY, UKRAINE.

出版信息

Pol Merkur Lekarski. 2023;51(1):42-47. doi: 10.36740/Merkur202301106.

Abstract

OBJECTIVE

Aim: To study the species composition of microorganisms isolated from patients with otomycosis, and to control the sensitivity of isolated microorganisms to the most commonly used antifungal drugs.

PATIENTS AND METHODS

Materials and methods: The main group of study was 132 patients with a preliminary diagnosis of Otomycosis was carried out in the period 2020-2022.To study the sensitivity of isolated microorganisms to antifungal drugs, the Himedia paper disk method (India) was used.

RESULTS

Results: Analysis of studies showed that among 132 patients, fungal infection was found in 101 patients (76%), the cultural method - in 31 patients (23.5%); of them women - 56 (42.4%), men - 60 (45.5%) aged 16 to 76; children - 16 (12.1%) aged 6 to 12 years. However, among all patients (n = 132) with otomycosis, fungal lesions of the outer ear prevail, which were detected in 85 (64.4%) patients, that is, fungal otitis was detected in 47 (35.6%).

CONCLUSION

Conclusions: The general structure of the species spectrum of etiologically significant pathogens of otomycosis: Candida spp. (78.0%) of the total spectrum of isolates. The sensitivity of isolated micromycetes to antifungal drugs varied in different fungal species and in different antifungal drugs.

摘要

目的

目的:研究耳真菌病患者分离微生物的种属组成,并控制分离微生物对最常用抗真菌药物的敏感性。

患者和方法

材料和方法:主要研究组为 132 名初步诊断为耳真菌病的患者,研究时间为 2020-2022 年。为研究分离微生物对抗真菌药物的敏感性,采用 Himedia 纸片法(印度)。

结果

结果:研究分析表明,在 132 名患者中,101 名(76%)患者发现真菌感染,31 名(23.5%)采用培养法;其中女性 56 名(42.4%),男性 60 名(45.5%),年龄 16-76 岁;儿童 16 名(12.1%),年龄 6-12 岁。然而,在所有(n=132)耳真菌病患者中,外耳真菌感染较为常见,在 85 名(64.4%)患者中检测到,即真菌性中耳炎在 47 名(35.6%)患者中检测到。

结论

结论:耳真菌病的主要病原体的种属谱的总体结构:念珠菌属(78.0%)占总分离谱的比例。分离出的小型真菌对抗真菌药物的敏感性在不同真菌物种和不同抗真菌药物中存在差异。

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