Department of Microbiology, Faculty of Science & Informatics, University of Szeged, Szeged, Hungary.
Mycoses. 2012 Jul;55(4):333-8. doi: 10.1111/j.1439-0507.2011.02103.x. Epub 2011 Sep 7.
Black aspergilli are among the main causative agents of otomycosis worldwide. In this study, the species assignment of black aspergilli isolated from otomycosis cases in Iran was carried out using sequence analysis of part of the calmodulin gene. The results indicate that Aspergillus niger is not the only black Aspergillus species involved in otomycosis cases in Iran: Aspergillus awamori and Aspergillus tubingensis are also able to cause ear infections. Antifungal susceptibility tests were carried out against five antifungal drugs including amphotericin B, fluconazole, itraconazole, ketoconazole and terbinafine. All isolates were highly susceptible to terbinafine, while they exhibited moderate susceptibilities against amphotericin B, fluconazole and ketoconazole. Aspergillus niger and A. awamori were found to have higher minimal inhibitory concentrations for azoles than A. tubingensis, in accordance with previous findings.
黑曲霉是全球范围内引起耳真菌病的主要病原体之一。在这项研究中，通过对钙调蛋白基因部分序列的分析，对从伊朗耳真菌病病例中分离出的黑曲霉进行了种属鉴定。结果表明，黑曲霉并不是引起伊朗耳真菌病的唯一黑曲霉物种：棘孢曲霉和土曲霉也能够引起耳部感染。对包括两性霉素 B、氟康唑、伊曲康唑、酮康唑和特比萘芬在内的五种抗真菌药物进行了药敏试验。所有分离株均对特比萘芬高度敏感，而对两性霉素 B、氟康唑和酮康唑表现出中度敏感性。与之前的研究结果一致，棘孢曲霉和土曲霉对唑类药物的最小抑菌浓度高于烟曲霉。
