Yu J, Shao L E, Lemas V, Yu A L, Vaughan J, Rivier J, Vale W
Department of Molecular Biology, Research Institute of Scripps Clinic, La Jolla, California 92037.
Nature. 1987;330(6150):765-7. doi: 10.1038/330765a0.
Inhibin is a hypophysiotropic hormone which selectively suppresses the secretion of pituitary follicle-stimulating hormone. It has been isolated from gonadal fluids and characterized as a protein heterodimer consisting of an alpha subunit and one of two beta subunits (beta A or beta B). FSH-releasing protein (FRP), also named activin, is a dimer consisting of two inhibin beta-chains. A factor from conditioned medium of a leukaemia cell line has been isolated which can induce mouse Friend cells to become benzidine-positive, and which shares a similar N-terminal sequence with porcine FRP. In this report, we find that FRP and inhibin modulate both the induction of haemoglobin accumulation in a human erythroleukaemic cell line, K562, and the proliferation of erythroid progenitor cells in human bone marrow culture. These two proteins could constitute a novel humoral regulatory control of erythropoiesis which would involve two types of related protein dimers with functionally opposite effects.
抑制素是一种促垂体激素，它能选择性地抑制垂体促卵泡激素的分泌。它已从性腺液中分离出来，其特征是一种蛋白质异二聚体，由一个α亚基和两个β亚基（βA或βB）之一组成。促卵泡激素释放蛋白（FRP），也称为激活素，是一种由两条抑制素β链组成的二聚体。已从一种白血病细胞系的条件培养基中分离出一种因子，它能诱导小鼠Friend细胞变成联苯胺阳性，并且与猪FRP具有相似的N端序列。在本报告中，我们发现FRP和抑制素既能调节人红白血病细胞系K562中血红蛋白积累的诱导过程，也能调节人骨髓培养中红系祖细胞的增殖。这两种蛋白质可能构成一种新型的造血体液调节控制机制，该机制涉及两种功能相反的相关蛋白质二聚体。
