Kassir Ghida, El Hayek Samer, Charara Raghid, Cherro Michele, Itani Hala, El Khoury Joseph
Department of Psychiatry, American University of Beirut, Beirut, Lebanon.
Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, Miami, Florida, United States of America.
PLOS Glob Public Health. 2022 Dec 28;2(12):e0001428. doi: 10.1371/journal.pgph.0001428. eCollection 2022.
Schizophrenia is a chronic, debilitating mental illness that contributes significantly to the global burden of disease. Assertive outreach treatment for patients with schizophrenia and psychotic disorders has been implemented to improve treatment adherence and outcomes. The suitability of this model of care outside the western context has not been fully established. We describe the characteristics of 45 patients enrolled in the Psychosis Recovery Outreach Program (PROP), a program developed at a leading psychiatric facility in Lebanon. We collected twelve-month data for patients and used logistic regression models to identify predictor variables for enrollment in the service compared to those receiving standard treatment. Patients were mostly males (77.8%), younger than 39 years (80%), of college or higher education (68.2%), and diagnosed with schizophrenia (46.7%) or schizoaffective disorder (48.9%). About one-quarter (22.7%) had a comorbid cannabis use disorder. A majority received more than one oral antipsychotic (75.6%) while half (51.1%) were maintained on a long-acting injectable (LAI) antipsychotic. The following variables were significant predictors of enrollment in PROP: having a comorbid cannabis use disorder (OR 2.83 [1.25 - 6.37]), being prescribed a LAI antipsychotic (OR 9.99 [4.93-20.24]) or more than one oral antipsychotic (OR 4.57 [2.22-9.39]), visiting the emergency department more than once (OR 8.7 [2.64-28.68]), and admission to the psychiatry unit (OR 13.91 [3.17-60.94]). In addition, those following up in PROP were younger and less likely to be in the oldest age group (over 54 years) [OR 0.11 (0.01-0.93)], less likely to be females (OR 0.39 [0.18-0.81]), and less likely to be diagnosed with "other psychotic disorder" as compared to schizophrenia (OR 0.14 [0.03 - 0.62]). Our findings highlight that the assertive outreach model of care is applicable to its target population in the context of psychiatric care in Lebanon, namely young individuals with psychosis, higher comorbidities and a severe course of illness.
精神分裂症是一种慢性、使人衰弱的精神疾病,在全球疾病负担中占很大比重。针对精神分裂症和精神障碍患者实施了积极外展治疗,以提高治疗依从性和改善治疗效果。这种护理模式在西方背景之外的适用性尚未完全确立。我们描述了参与精神病康复外展项目(PROP)的45名患者的特征,该项目是黎巴嫩一家领先的精神病设施开发的。我们收集了患者的十二个月数据,并使用逻辑回归模型来确定与接受标准治疗的患者相比,参与该服务的预测变量。患者大多为男性(77.8%),年龄小于39岁(80%),具有大专或以上学历(68.2%),被诊断为精神分裂症(46.7%)或分裂情感性障碍(48.9%)。约四分之一(22.7%)患有合并大麻使用障碍。大多数患者接受了不止一种口服抗精神病药物(75.6%),而一半(51.1%)患者使用长效注射(LAI)抗精神病药物维持治疗。以下变量是参与PROP项目的显著预测因素:患有合并大麻使用障碍(比值比[OR] 2.83 [1.25 - 6.37])、被处方使用LAI抗精神病药物(OR 9.99 [4.93 - 20.24])或不止一种口服抗精神病药物(OR 4.57 [2.22 - 9.39])、多次前往急诊科(OR 8.7 [2.64 - 28.68])以及入住精神科病房(OR 13.91 [3.17 - 60.94])。此外,参与PROP项目随访的患者更年轻,不太可能属于最年长年龄组(54岁以上)[OR 0.11 (0.01 - 0.93)],女性可能性较小(OR 0.39 [0.18 - 0.81]),与精神分裂症相比,被诊断为“其他精神障碍”的可能性较小(OR 0.14 [0.03 - 0.62])。我们的研究结果表明,积极外展护理模式适用于黎巴嫩精神病护理背景下的目标人群,即患有精神病、合并症较多且病情严重的年轻个体。