Department of Endocrine and Metabolic Diseases, Istituto Auxologico Italiano IRCCS, Milan, Italy; BIOMETRA, University of Milan, Milan, Italy.
BIOMETRA, University of Milan, Milan, Italy.
Ann Endocrinol (Paris). 2023 May;84(3):367-369. doi: 10.1016/j.ando.2023.03.008. Epub 2023 Mar 22.
Factitious thyrotoxicosis (FTT) is a common form of thyroid hormone (TH) abuse involving voluntary but concealed intake of an excessive amount of TH. In most cases, FTT seeks to improve body composition with a decrease in body fat and weight while maintaining apparent fitness. It is frequent in Munchausen syndrome, to attract attention for care. It can involve excessive intake either of thyroxine (T4) or of thyroid extracts or liothyronine (T3). In addition, several dietary supplements available on-line were shown to contain clinically relevant amounts of T4 and T3. TH abuse also occurs in elite athletes and bodybuilders, to reach the appropriate weight and prioritize fat loss. Diagnosis should be suspected whenever the typical features of hyperthyroidism or endogenous thyrotoxicosis are not present, as prolonged overlooked TH abuse can lead to severe consequences, including life-threatening events.
人为性甲状腺毒症（FTT）是一种常见的甲状腺激素（TH）滥用形式，涉及自愿但隐瞒地摄入过量的 TH。在大多数情况下，FTT 旨在通过减少体脂和体重来改善身体成分，同时保持明显的健康。它在孟乔森综合征中很常见，以引起关注。它可能涉及过量摄入甲状腺素（T4）或甲状腺提取物或三碘甲状腺原氨酸（T3）。此外，网上有几种膳食补充剂被证明含有临床相关量的 T4 和 T3。TH 滥用也发生在精英运动员和健美运动员中，以达到适当的体重和优先考虑脂肪减少。只要不存在典型的甲状腺功能亢进或内源性甲状腺毒症特征，就应怀疑诊断，因为长期被忽视的 TH 滥用可能导致严重后果，包括危及生命的事件。
