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过硫酸盐盐增强放射荧光水凝胶的 X 射线剂量响应。

Enhanced X-ray Dose Response of Radio-fluorescent Hydrogels Enabled by Persulfate Salts.

机构信息

State Key Laboratory of Radiation Medicine and Protection, Collaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education Institutions, School for Radiological and Interdisciplinary Sciences (RAD-X), Suzhou Medical College of Soochow University, Soochow University, Suzhou, China.

出版信息

J Fluoresc. 2023 Sep;33(5):2015-2021. doi: 10.1007/s10895-023-03205-3. Epub 2023 Mar 25.

DOI:10.1007/s10895-023-03205-3
PMID:36964847
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10039678/
Abstract

Coumarin 3-carboxylic acid (CCA)-loaded radio-fluorescent hydrogels have attracted interest for ionizing radiation dosimeters, but their sensitivity needs to be improved. In this study, we added ammonium persulfate (APS) to a polyacrylamide (PAAm)-CCA hydrogel. The introduction of APS improved the hydrogel dose sensitivity to 336.02 Gy, which is 1.8 times that of the counterpart without APS. Our hydrogel can measure the X-ray dose in a range of 0 - 15 Gy with a lower limit of detection (LOD) of 0.1 Gy. Additionally, the hydrogel can sense X-ray doses within a wide range of the dose rate and temperature, and the dose‒response can be well retained 7 days postirradiation. Therefore, we think this study provides a simple and robust method to improve the sensitivity of CCA hydrogel dosimeters, presenting great potential in clinical radiotherapy.

摘要

香豆素 3-羧酸（CCA）负载的放射性荧光水凝胶因其可用作离子辐射剂量计而受到关注，但它们的灵敏度需要提高。在本研究中，我们在聚丙烯酰胺（PAAm）-CCA 水凝胶中添加了过硫酸铵（APS）。APS 的引入将水凝胶的剂量灵敏度提高到 336.02 Gy，是没有 APS 的对应物的 1.8 倍。我们的水凝胶可以测量 0-15 Gy 范围内的 X 射线剂量，检测限（LOD）为 0.1 Gy。此外，该水凝胶可以在宽剂量率和温度范围内感知 X 射线剂量，并且在辐照后 7 天内仍能很好地保留剂量响应。因此，我们认为这项研究为提高 CCA 水凝胶剂量计的灵敏度提供了一种简单而稳健的方法，在临床放射治疗中具有很大的应用潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6556/10039678/e2ad57eb4681/10895_2023_3205_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6556/10039678/ed6d0d07584d/10895_2023_3205_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6556/10039678/b740d2881fcd/10895_2023_3205_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6556/10039678/8c7cb91be83c/10895_2023_3205_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6556/10039678/7ba03bbc8d2f/10895_2023_3205_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6556/10039678/9b99140b1305/10895_2023_3205_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6556/10039678/97f217eadde6/10895_2023_3205_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6556/10039678/dcc6874c86d1/10895_2023_3205_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6556/10039678/9a28a89231ae/10895_2023_3205_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6556/10039678/e2ad57eb4681/10895_2023_3205_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6556/10039678/ed6d0d07584d/10895_2023_3205_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6556/10039678/b740d2881fcd/10895_2023_3205_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6556/10039678/8c7cb91be83c/10895_2023_3205_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6556/10039678/7ba03bbc8d2f/10895_2023_3205_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6556/10039678/9b99140b1305/10895_2023_3205_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6556/10039678/97f217eadde6/10895_2023_3205_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6556/10039678/dcc6874c86d1/10895_2023_3205_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6556/10039678/9a28a89231ae/10895_2023_3205_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6556/10039678/e2ad57eb4681/10895_2023_3205_Fig9_HTML.jpg

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