Department of Oral and Maxillofacial Surgery, Hospital of Stomatology, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Stomatology, Guangzhou, China.
Oral Dis. 2024 Jul;30(5):2894-2906. doi: 10.1111/odi.14575. Epub 2023 Apr 10.
A hypercoagulable state exists in patients with oral squamous cell carcinoma (OSCC), but the role of platelets in the tumour microenvironment has not been explored. This study revealed the status of intratumoral plateletmicrothrombi (PLT-MT) and their clinicopathological relevance and predictive value in OSCC.
This study retrospectively evaluated 106 OSCC patients. Tumour and tumour-adjacent tissue specimens were used to stain PLT-MT. Clinicopathological information, patient follow-ups and outcomes and preoperative coagulation and inflammatory hematologic indicators were collected, and their correlation with PLT-MT was analysed.
Intratumoral PLT-MT was present in 35 of 106 patients with OSCC who had higher preoperative D-dimer, CRP, FIB and PT levels and lower TT levels. PLT-MT was an independent correlative factor of lymph node metastasis and suggested worse OS in N0 patients.
Intratumoral PLT-MT was found in OSCC and was correlated with a hypercoagulable inflammatory state. PLT-MT was an independent marker of lymph node metastasis and showed potential in prognosis prediction.
口腔鳞状细胞癌（OSCC）患者存在高凝状态，但血小板在肿瘤微环境中的作用尚未得到探索。本研究揭示了肿瘤内血小板微血栓（PLT-MT）的状态及其在 OSCC 中的临床病理相关性和预测价值。
本研究回顾性评估了 106 例 OSCC 患者。使用肿瘤和肿瘤邻近组织标本对 PLT-MT 进行染色。收集临床病理信息、患者随访和结局以及术前凝血和炎症血液学指标，并分析其与 PLT-MT 的相关性。
106 例 OSCC 患者中有 35 例存在肿瘤内 PLT-MT，这些患者术前 D-二聚体、CRP、FIB 和 PT 水平较高，TT 水平较低。PLT-MT 是淋巴结转移的独立相关因素，并提示 N0 患者的总生存期较差。
OSCC 中存在肿瘤内 PLT-MT，与高凝炎症状态相关。PLT-MT 是淋巴结转移的独立标志物，具有预后预测的潜力。
