Department of Oral and Maxillofacial Surgery, Hospital of Stomatology, Sun Yat-sen University, Guangzhou, China.
Guangdong Provincial Key Laboratory of Stomatology, Sun Yat-sen University, Guangzhou, China.
BMC Cancer. 2024 Sep 11;24(1):1136. doi: 10.1186/s12885-024-12868-5.
A variety of solid tumours, including oral squamous cell carcinoma (OSCC), can cause coagulation abnormalities, and this phenomenon is known as tumour-associated hypercoagulation. We aimed to explore the preoperative thromboelastography (TEG) parameter profiles of OSCC patients, and to investigate their trends in relation to tumour stage progression, and to evaluate their value for predicting cervical lymph node metastasis.
Data on thromboelastographic parameters and conventional coagulation indices were retrospectively collected, and comparisons were performed among preoperative primary OSCC patients (n = 311), recurrent/metastatic OSCC patients (n = 44) and a control group (n = 71). Among primary OSCC patients, the correlation with tumour stage and the predictive role of cervical lymph node metastasis were analyzed.
Hypercoagulability occurred in OSCC patients and tended to become more pronounced as the tumour progressed. The whole-time phase of coagulation increased with increasing T stage, while the early phase of coagulation increased with increasing N stage.
Preoperative TEG parameters are closely related to tumour stage and progression, suggesting that TEG can be used as an important indicator for predicting tumour stage and as a potential biomarker.
多种实体瘤，包括口腔鳞状细胞癌（OSCC），可导致凝血异常，这种现象被称为肿瘤相关性高凝。我们旨在探讨 OSCC 患者术前血栓弹力图（TEG）参数特征，并研究其与肿瘤分期进展的趋势，评估其对预测颈部淋巴结转移的价值。
回顾性收集血栓弹力图参数和常规凝血指数数据，并对术前原发性 OSCC 患者（n=311）、复发性/转移性 OSCC 患者（n=44）和对照组（n=71）进行比较。在原发性 OSCC 患者中，分析与肿瘤分期的相关性及对颈部淋巴结转移的预测作用。
OSCC 患者存在高凝状态，且随着肿瘤进展，这种趋势变得更加明显。凝血的整体时间阶段随着 T 分期的增加而增加，而早期凝血阶段随着 N 分期的增加而增加。
术前 TEG 参数与肿瘤分期和进展密切相关，提示 TEG 可作为预测肿瘤分期的重要指标，并可能成为一种潜在的生物标志物。
