冷冻断裂显示兔视网膜中米勒细胞终足的异质性。
Heterogeneity of Müller cell endfeet in the rabbit retina as revealed by freeze-fracturing.
作者信息
Wolburg H, Berg K
机构信息
Pathologisches Institut, Universität Tübingen, F.R.G.
出版信息
Neurosci Lett. 1987 Dec 4;82(3):273-7. doi: 10.1016/0304-3940(87)90268-0.
The Müller cell membranes of the rabbit retina were investigated by means of freeze-fracturing. Orthogonal arrays of particles (OAP) were found almost exclusively where the Müller cell endfoot had direct contact with the vitreous body. In the center of the retina where the Müller cells are long and thin, the density of OAP was about 170/microns2. In the periphery where the Müller cells are shorter and thicker, the density of OAP was about 20/microns2. In this area, only half of the Müller cell endfeet were equipped with OAP. The results are discussed with respect to electrophysiological studies on the role of various K+ channels in glial cells. It is proposed that OAP might possibly represent specialized 'maxi'-K+ channels which are involved in K+ spatial buffering of the extracellular space.
通过冷冻断裂技术对兔视网膜的米勒细胞膜进行了研究。几乎仅在米勒细胞终足与玻璃体直接接触的地方发现了正交颗粒阵列（OAP）。在视网膜中央，米勒细胞又长又细，OAP的密度约为170个/平方微米。在视网膜周边，米勒细胞更短更粗，OAP的密度约为20个/平方微米。在该区域，只有一半的米勒细胞终足配备有OAP。结合关于各种钾离子通道在神经胶质细胞中作用的电生理研究对结果进行了讨论。有人提出，OAP可能代表专门的“大电导”钾离子通道，参与细胞外空间的钾离子空间缓冲。
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