Department of Cardiology, Erasmus Medical Center, Rotterdam, The Netherlands.
Department of Cardiology, Ikazia Hospital, Rotterdam, The Netherlands.
ESC Heart Fail. 2023 Jun;10(3):2074-2083. doi: 10.1002/ehf2.14354. Epub 2023 Mar 25.
Heart failure (HF) is a progressive disease in which periods of clinical stability are interrupted by episodes of clinical deterioration known as worsening heart failure (WHF). Patients who develop WHF are at high risk of subsequent death, rehospitalization, and excessive healthcare costs. As such, WHF could be seen as a separate disease stage and precursor of advanced HF. Whether WHF has a substantial health, societal, and economic impact evidence regarding its multifactorial nature and the specific barriers in treatment, including advanced HF therapies, remains scarce. The CHAIN-HF registry aims to describe the incidence, characteristics, current treatment, and outcomes of WHF. Additionally, it will promote structured regional collaboration and educate on increasing awareness for WHF and describe the implementation of guideline directed medical therapy and utilization of advanced HF therapies in a collaborative network.
The CHAIN-HF registry is a prospective, observational, and multicentre study from the collaborating hospitals (Rijnmond HF Network) in the Rotterdam area. Unselected and consecutive patients (irrespective of ejection fraction) with a WHF event will be included. Comprehensive data including demographics, co-morbidities, treatment, and in-hospital and post-discharge outcomes will be collected. Notably, data on socio-economic status, treatment decisions, and referral for advanced HF therapies will be included.
CHAIN-HF will be the first prospective, dedicated WHF registry in a collaborative network of hospitals that will provide robust real-world evidence on the incidence, characteristics, and outcomes of WHF. Moreover, it will provide information on of the value of regional collaboration to improve awareness and outcomes of WHF.
心力衰竭（HF）是一种进行性疾病，其临床稳定期会被称为恶化性心力衰竭（WHF）的临床恶化期所打断。出现 WHF 的患者有很高的后续死亡、再住院和过度医疗费用风险。因此，WHF 可以被视为一个独立的疾病阶段和晚期 HF 的前兆。WHF 是否对健康、社会和经济有重大影响，这方面的证据尚不足，其多因素性质以及治疗方面的具体障碍，包括晚期 HF 治疗，仍然很少。CHAIN-HF 登记处旨在描述 WHF 的发生率、特征、当前治疗和结局。此外，它将促进结构化的区域合作，提高对 WHF 的认识，并描述指南指导的医疗治疗的实施和在协作网络中对先进 HF 治疗的利用。
CHAIN-HF 登记处是一项来自鹿特丹地区合作医院（Rijnmond HF 网络）的前瞻性、观察性和多中心研究。将纳入出现 WHF 事件的未经选择的连续患者（不分射血分数）。将收集包括人口统计学、合并症、治疗以及住院和出院后结局在内的综合数据。值得注意的是，将包括社会经济地位、治疗决策和转诊至先进 HF 治疗的数据。
CHAIN-HF 将是首个在协作医院网络中进行的前瞻性、专门针对 WHF 的登记处，将提供关于 WHF 的发生率、特征和结局的强有力的真实世界证据。此外，它将提供关于区域合作提高 WHF 认识和结局的价值的信息。
