HIV-1 亚型 B 和 C 感染者脑脊液中的 CD3CD56 和 CD3CD56 淋巴细胞。
CD3CD56 and CD3CD56 lymphocytes in the cerebrospinal fluid of persons with HIV-1 subtypes B and C.
机构信息
Virology Laboratory, Hospital de Clínicas, Universidade Federal do Paraná, Curitiba, PR, Brazil.
Immunophenotyping Laboratory, Hospital de Clínicas, Universidade Federal do Paraná, Curitiba, PR, Brazil.
出版信息
J Neuroimmunol. 2023 Apr 15;377:578067. doi: 10.1016/j.jneuroim.2023.578067. Epub 2023 Mar 17.
The transactivator of transcription (Tat) is a HIV regulatory protein which promotes viral replication and chemotaxis. HIV-1 shows extensive genetic diversity, HIV-1 subtype C being the most dominant subtype in the world. Our hypothesis is the frequency of CSF CD3CD56 and CD3CD56 is reduced in HIV-1C compared to HIV-1B due to the Tat C30S31 substitution in HIV-1C. 34 CSF and paired blood samples (PWH, n = 20; PWoH, n = 14) were studied. In PWH, the percentage of CD3CD56 was higher in CSF than in blood (p < 0.001), comparable in both compartments in PWoH (p = 0.20). The proportion of CD3CD56 in CSF in PWH was higher than PWoH (p = 0.008). There was no subtype differences. These results showed CNS compartmentalization of NKT cell response in PWH.
转录激活物（Tat）是一种 HIV 调节蛋白，可促进病毒复制和趋化性。HIV-1 表现出广泛的遗传多样性，HIV-1 亚型 C 是世界上最主要的亚型。我们的假设是，由于 HIV-1C 中的 Tat C30S31 取代，与 HIV-1B 相比，HIV-1C 中 CSF CD3CD56 和 CD3CD56 的频率降低。研究了 34 例 CSF 和配对的血液样本（PWH，n=20；PWoH，n=14）。在 PWH 中，CSF 中 CD3CD56 的百分比高于血液（p<0.001），在 PWoH 中两个部位相当（p=0.20）。PWH 中 CSF 中 CD3CD56 的比例高于 PWoH（p=0.008）。没有亚型差异。这些结果表明，在 PWH 中，NKT 细胞反应存在中枢神经系统区室化。
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