Singh Gurmeet, Singh Amritpal, Kumar Neeraj, Avti Pramod
Department of Mechanical Engineering, Thapar Institute of Engineering & Technology, Patiala 147004, India; Virginia Tech-TIET- Center of Excellence in Emerging Materials, Thapar Institute of Engineering & Technology, Patiala 147001, India.
Department of Mechanical Engineering, Thapar Institute of Engineering & Technology, Patiala 147004, India.
Med Eng Phys. 2023 Mar;113:103965. doi: 10.1016/j.medengphy.2023.103965. Epub 2023 Feb 26.
Effects of injection rate and tumor physiology on the diffusion of magnetic nano-particles (MNPs) and temperature profile during magnetic hyperthermia are investigated in this work. The study considers three injection rates (2.5 μL/min, 10 μL/min, and 40 μL/min), and two MNP diffusion coefficients (10 m/s and 10 m/s). The simulation of this physics has been done on 3D tumor surrounded by healthy tissue. Transient MNP distribution in tissue is evaluated using Darcy's flow model and the MNP transport (convection-diffusion) equation. The temperature profile in the tumor model is computed by solving Penne's bioheat transfer equation (PBHTE). Results show tumors with high collagen content (with low MNP diffusivity) are more restrictive towards MNP transport than tumors having low collagen content. Thus, tumors with low MNP diffusivity need a higher injection rate to increase the homogeneity of MNP concentration as well as temperature profile during thermo-therapy. Results also show that, MNP fluid injected with a higher injection rate produces a more uniform MNP concentration up to greater depth than the lower injection rate.
本研究探讨了注射速率和肿瘤生理学对磁性纳米颗粒（MNPs）扩散以及磁热疗期间温度分布的影响。该研究考虑了三种注射速率（2.5 μL/分钟、10 μL/分钟和40 μL/分钟）以及两种MNP扩散系数（10米/秒和10米/秒）。对由健康组织包围的三维肿瘤进行了该物理过程的模拟。使用达西流模型和MNP输运（对流扩散）方程评估组织中的瞬态MNP分布。通过求解彭尼生物热传递方程（PBHTE）计算肿瘤模型中的温度分布。结果表明，胶原蛋白含量高（MNP扩散率低）的肿瘤对MNP输运的限制比胶原蛋白含量低的肿瘤更大。因此，MNP扩散率低的肿瘤在热疗期间需要更高的注射速率来提高MNP浓度的均匀性以及温度分布。结果还表明，以较高注射速率注入的MNP流体在比低注射速率更大的深度范围内产生更均匀的MNP浓度。
