Astefanoaei Iordana, Gimaev Radel, Zverev Vladimir, Tishin Alexander, Stancu Alexandru
Faculty of Physics, Alexandru Ioan Cuza University of Iasi, 700506 Iaşi, Romania.
Faculty of Physics, M. V. Lomonosov Moscow State University, Moscow 119991, Russia.
Nanomaterials (Basel). 2023 Aug 21;13(16):2383. doi: 10.3390/nano13162383.
Magnetic nanoparticles (MNPs) with various shapes and special (magnetic and thermal) properties are promising for magnetic hyperthermia. The efficiency of this therapy depends mainly on the MNPs' physical characteristics: types, sizes and shapes. This paper presents the hyperthermic temperature values induced by cubic/sphere-shaped MNPs injected within a concentric tissue configuration (malignant and healthy tissues) when an external time-dependent magnetic field was applied. The space-time distribution of the nanoparticles as a result of their injection within a tumoral (benign/malign) tissue was simulated with the bioheat transport equation (Pennes equation). A complex thermo-fluid model that considers the space-time MNP transport and its heating was developed in Comsol Multiphysics. The cubic-shaped MNPs give a larger spatial distribution of the therapeutic temperature in the tumoral volume compared to the spherical-shaped ones. MNP doses that induce the therapeutic (hyperthermic) values of the temperature (40 ÷ 45 °C) in smaller volumes from the tumoral region were analyzed. The size of these regions (covered by the hyperthermic temperature values) was computed for different magnetite cubic/sphere-shaped MNP doses. Lower doses of the cubic-shaped MNPs give the hyperthermic values of the temperature in a larger volume from the tumoral region compared with the spheric-shaped MNPs. The MNP doses were expressed as a ratio between mass concentration and the maximum clinical accepted doses. This thermo-fluid analysis is an important computational instrument that allows the computations of the MNP doses that give therapeutic temperature values within tissues.
具有各种形状和特殊（磁性和热学）性质的磁性纳米颗粒（MNPs）在磁热疗方面具有广阔前景。这种疗法的效率主要取决于MNPs的物理特性：类型、尺寸和形状。本文展示了在施加随时间变化的外部磁场时，注入同心组织构型（恶性和健康组织）内的立方体形/球形MNPs所诱导的热疗温度值。利用生物热传输方程（彭尼斯方程）模拟了纳米颗粒注入肿瘤（良性/恶性）组织后其在时空上的分布。在Comsol Multiphysics中开发了一个考虑时空MNP传输及其加热的复杂热流体模型。与球形MNPs相比，立方体形MNPs在肿瘤体积内的治疗温度空间分布更大。分析了在肿瘤区域较小体积内诱导治疗（热疗）温度值（40÷45°C）的MNP剂量。针对不同的磁铁矿立方体形/球形MNP剂量，计算了这些区域（被热疗温度值覆盖）的大小。与球形MNPs相比，较低剂量的立方体形MNPs在肿瘤区域更大体积内产生热疗温度值。MNP剂量表示为质量浓度与最大临床可接受剂量之间的比值。这种热流体分析是一种重要的计算工具，可用于计算在组织内产生治疗温度值的MNP剂量。
