黑人女性中，血压变异性与绝经状态下内皮素-1 的关系：来自杰克逊心脏研究的结果。
Association of blood pressure variability with Endothelin-1 by menopause status among Black women: findings from the Jackson Heart Study.
机构信息
Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
Division of Cardiology, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
出版信息
J Hum Hypertens. 2023 Aug;37(8):742-745. doi: 10.1038/s41371-023-00824-y. Epub 2023 Mar 25.
Postmenopausal women have a higher risk of hypertension compared with premenopausal women possibly related to increased endothelial dysfunction in the setting of lower levels of circulating estrogen. Using data from 660 women in the Jackson Heart Study (JHS), postmenopausal women had higher daytime, nighttime and 24 h systolic blood pressure variability (BPV) compared with premenopausal women, and higher nighttime systolic BPV was associated with higher endothlin-1 (a marker of endothelial dysfunction) in postmenopausal women (ß = 0.27 [0.05, 0.50], p = 0.019), even after adjustment for possible confounders including age. These findings highlight the relevance of menopause status to blood pressure variability and the potential role of blood pressure variability in the development of high endothelin-1 in postmenopausal women.
绝经后女性患高血压的风险高于绝经前女性，这可能与循环雌激素水平较低导致的内皮功能障碍增加有关。利用杰克逊心脏研究（JHS）中 660 名女性的数据，与绝经前女性相比，绝经后女性的日间、夜间和 24 小时收缩压变异性（BPV）更高，且绝经后女性的夜间收缩压 BPV 较高与内皮素-1 较高相关（内皮功能障碍的标志物）（β=0.27 [0.05，0.50]，p=0.019），即使在调整了包括年龄在内的可能混杂因素后也是如此。这些发现强调了绝经状态与血压变异性的相关性，以及血压变异性在绝经后女性高内皮素-1 发展中的潜在作用。
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