Department of Cardiology, Shengjing Hospital of China Medical University, Shenyang, Liaoning, China.
Department of Neurology, Shengjing Hospital of China Medical University, Shenyang, Liaoning, China.
Biomed Pharmacother. 2023 Jun;162:114581. doi: 10.1016/j.biopha.2023.114581. Epub 2023 Mar 24.
Puerarin is an isoflavone compound derived from Pueraria lobata in traditional Chinese medicine. Accumulating evidence has indicated that puerarin demonstrates multiple pharmacological effects and exhibits treatment potential for various neurological disorders. Based on the latest research progress on puerarin as a neuroprotective agent, its pharmacological activity, molecular mechanism, and therapeutic application were systematically reviewed with emphasis on pre-clinical studies. The related information was extracted and compiled from major scientific databases, including PubMed, ScienceDirect, SpringerLink, and Chinese National Knowledge Infrastructure, using 'Puerarin', 'Neuroprotection', 'Apoptosis', 'Autophagy', 'Antioxidant', 'Mitochondria', 'Anti-inflammation' as keywords. This review complied with The Preferred Reporting Items for Systematic Reviews criteria. Forty-three articles met established inclusion and exclusion criteria. Puerarin has shown neuroprotective effects against a variety of neurological disorders, including ischemic cerebrovascular disease, subarachnoid hemorrhage, epilepsy, cognitive disorders, traumatic brain injury, Parkinson's disease, Alzheimer's disease, anxiety, depression, diabetic neuropathy, and neuroblastoma/glioblastoma. Puerarin demonstrates anti-apoptosis, proinflammatory mediator inhibitory, autophagy regulatory, anti-oxidative stress, mitochondria protection, Ca influx inhibitory, and anti-neurodegenerative activities. Puerarin exerts noticeable neuroprotective effects on various models of neurological disorders in vivo (animal). This review will contribute to the development of puerarin as a novel clinical drug candidate for the treatment of neurological disorders. However, well-designed, high-quality, large-scale, multicenter randomized clinical studies are needed to determine the safety and clinical utility of puerarin in patients with neurological disorders.
葛根素是一种来源于中药葛根的异黄酮化合物。越来越多的证据表明，葛根素具有多种药理作用，对多种神经退行性疾病具有治疗潜力。基于葛根素作为神经保护剂的最新研究进展，本文系统综述了其药理学作用、分子机制和治疗应用，重点是临床前研究。使用“葛根素”、“神经保护”、“细胞凋亡”、“自噬”、“抗氧化”、“线粒体”、“抗炎”等关键词，从 PubMed、ScienceDirect、SpringerLink 和中国知网等主要科学数据库中提取和编译相关信息。本综述符合系统评价的首选报告项目标准。符合既定纳入和排除标准的有 43 篇文章。葛根素对多种神经退行性疾病具有神经保护作用，包括缺血性脑血管病、蛛网膜下腔出血、癫痫、认知障碍、创伤性脑损伤、帕金森病、阿尔茨海默病、焦虑症、抑郁症、糖尿病性周围神经病和神经母细胞瘤/胶质母细胞瘤。葛根素具有抗细胞凋亡、抑制促炎介质、调节自噬、抗氧化应激、保护线粒体、抑制 Ca 内流和抗神经退行性作用。葛根素对体内（动物）多种神经退行性疾病模型具有显著的神经保护作用。本综述将有助于将葛根素开发为治疗神经退行性疾病的新型临床候选药物。然而，需要进行精心设计、高质量、大规模、多中心的随机临床试验，以确定葛根素在神经退行性疾病患者中的安全性和临床实用性。
