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葛根素作为脂质代谢的多靶点调节剂：分子机制、治疗潜力及营养转化前景

Puerarin as a multi-targeted modulator of lipid metabolism: molecular mechanisms, therapeutic potential and prospects for nutritional translation.

作者信息

Ou Shu, Liang Qingzhi, Leng Yulin, Luo Ting, Xu Xin, Xie Hongyan, Gao Hong, Li Jun, Xie Chunguang

机构信息

Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.

TCM Regulating Metabolic Diseases Key Laboratory of Sichuan Province, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.

出版信息

Front Nutr. 2025 Jul 18;12:1598897. doi: 10.3389/fnut.2025.1598897. eCollection 2025.

DOI:10.3389/fnut.2025.1598897
PMID:40756564
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12314662/
Abstract

Lipid metabolism is a dynamic and intricate process involving the uptake, synthesis, storage and catabolism of lipid compounds in the body. Its homeostasis is crucial for maintaining the health of the organism. The regulatory network of lipid metabolism homeostasis consists of several key molecules, including SREBPs, PPARs, ChREBP, FXR, LXR, AMPK, and ncRNAs. Puerarin (Pue), an isoflavone derivative, has been demonstrated to enhance lipid metabolism by modulating the aforementioned signaling cascades. Pue has found extensive application in the pharmaceutical, food, and nutraceutical industries. Considering the multi-target and multi-pathway pharmacological properties of Pue, the present study focuses on the molecular mechanism of Pue in the regulation of lipid metabolism, the spectrum of metabolic diseases, as well as the limitations of the current study and the prospect of nutritional translation. It is hoped that this study will provide a reference for the regulation of lipid homeostasis and remodeling of lipid metabolism, with the aim of optimizing clinical use and product development.

摘要

脂质代谢是一个动态且复杂的过程，涉及体内脂质化合物的摄取、合成、储存和分解代谢。其稳态对于维持机体健康至关重要。脂质代谢稳态的调控网络由几个关键分子组成，包括固醇调节元件结合蛋白（SREBPs）、过氧化物酶体增殖物激活受体（PPARs）、碳水化合物反应元件结合蛋白（ChREBP）、法尼醇X受体（FXR）、肝X受体（LXR）、腺苷酸活化蛋白激酶（AMPK）和非编码RNA（ncRNAs）。葛根素（Pue）是一种异黄酮衍生物，已被证明可通过调节上述信号级联反应来增强脂质代谢。葛根素在制药、食品和营养保健品行业有广泛应用。鉴于葛根素的多靶点和多途径药理特性，本研究聚焦于葛根素在脂质代谢调节中的分子机制、代谢疾病谱，以及当前研究的局限性和营养转化前景。希望本研究能为脂质稳态调节和脂质代谢重塑提供参考，以优化临床应用和产品开发。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f4b/12314662/fe721ec17ffb/fnut-12-1598897-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f4b/12314662/1759a713b258/fnut-12-1598897-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f4b/12314662/7e96ecf576f2/fnut-12-1598897-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f4b/12314662/fe721ec17ffb/fnut-12-1598897-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f4b/12314662/1759a713b258/fnut-12-1598897-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f4b/12314662/7e96ecf576f2/fnut-12-1598897-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f4b/12314662/fe721ec17ffb/fnut-12-1598897-g003.jpg

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本文引用的文献

[1]
Serum metabolomics and 16S rRNA amplicon sequencing reveal the role of puerarin in alleviating bone loss aggravated by antidiabetic agent pioglitazone in type 2 diabetic mice.

J Ethnopharmacol. 2025-1-31

[2]
Therapeutic targeting of senescent cells in the CNS.

Nat Rev Drug Discov. 2024-11

[3]
Preparation of cubic liquid crystal nanoparticles of puerarin and its protective effect on ischemic stroke.

Nanomedicine. 2024-11

[4]
The Role of Selected lncRNAs in Lipid Metabolism and Cardiovascular Disease Risk.

Int J Mol Sci. 2024-8-26

[5]
A brain-to-gut signal controls intestinal fat absorption.

Nature. 2024-10

[6]
Puerarin ameliorates non-alcoholic fatty liver disease by inhibiting lipid metabolism through FMO5.

Front Pharmacol. 2024-7-11

[7]
Understanding the cause of type 2 diabetes.

Lancet Diabetes Endocrinol. 2024-9

[8]
Metabolomic analysis of the Puerarin hypoglycemic activity via AMPK-mTOR and PPARγ-NF-κB signaling pathways.

Phytomedicine. 2024-7-25

[9]
Puerarin Affects 1HMR Spectroscopy Quantified Hepatic Fat Signal Fraction in Intrauterine Growth Restricted Rats.

Curr Med Imaging. 2024

[10]
Puerarin Modulates Hepatic Farnesoid X Receptor and Gut Microbiota in High-Fat Diet-Induced Obese Mice.

Int J Mol Sci. 2024-5-12

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