University of California, San Diego, Department of Pharmacology, 9500 Gilman Drive, La Jolla, CA 92093, USA.
University of California, San Diego, Department of Pharmacology, 9500 Gilman Drive, La Jolla, CA 92093, USA.
Curr Opin Chem Biol. 2023 Jun;74:102279. doi: 10.1016/j.cbpa.2023.102279. Epub 2023 Mar 24.
Eukaryotes depend upon the proper localization, accumulation, and release of intracellular Ca2+. This is regulated through specialized cellular compartments, signaling pathways, and Ca2+-binding proteins and channels. Cytosolic and extracellular signaling governing intracellular Ca2+ stores are well explored. However, regulatory signals within Ca2+ storage organelles like the endoplasmic/sarcoplasmic reticulum are not well understood. This is due to a lack of identified signaling molecules - like protein kinases - within these compartments, limited information on their regulation, and incomplete understanding of mechanisms involving modified substrates. Here we review recent advances in intralumenal signaling focusing on the secretory pathway protein kinase FAM20C and its regulation, Ca2+-binding protein substrates, and potential mechanisms through which FAM20C may regulate Ca2+ storage.
真核生物依赖于细胞内 Ca2+ 的正确定位、积累和释放。这是通过专门的细胞区室、信号通路以及 Ca2+结合蛋白和通道来调节的。细胞溶质和细胞外信号调节细胞内 Ca2+ 储存的机制已得到充分研究。然而，内质网/肌浆网等 Ca2+储存细胞器内的调节信号还不太清楚。这是由于这些区室中缺乏已识别的信号分子（如蛋白激酶）、对其调节的信息有限以及对涉及修饰底物的机制的理解不完整。在这里，我们回顾了腔内信号传递的最新进展，重点介绍了分泌途径蛋白激酶 FAM20C 及其调节、Ca2+结合蛋白底物以及 FAM20C 可能调节 Ca2+储存的潜在机制。
