硅酞菁类近红外光免疫治疗（NIR-PIT）的细胞毒性的化学基础及其对治疗监测的意义。
The chemical basis of cytotoxicity of silicon-phthalocyanine-based near infrared photoimmunotherapy (NIR-PIT) and its implications for treatment monitoring.
机构信息
Molecular Imaging Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD, 20892-1088, United States.
Molecular Imaging Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD, 20892-1088, United States.
出版信息
Curr Opin Chem Biol. 2023 Jun;74:102289. doi: 10.1016/j.cbpa.2023.102289. Epub 2023 Mar 24.
Abstract
Near infrared photoimmunotherapy (NIR-PIT) is a new cancer therapy based on the photo-induced ligand release reaction of a silicon-phthalocyanine derivative, IRDye700DX (IR700), that causes rapid cell death. Following exposure to an antibody-IR700-conjugate, cells exposed to NIR light within minutes undergo rapid swelling, blebbing, and finally, bursting. The photo-induced ligand release reaction also induces immediate loss of IR700 fluorescence due to dimerization or aggregation of the antibody-IR700 conjugate allowing for real time monitoring of NIR-PIT therapy.
摘要
近红外光免疫治疗（NIR-PIT）是一种基于硅酞菁衍生物 IRDye700DX（IR700）光诱导配体释放反应的新型癌症治疗方法，可导致细胞迅速死亡。在与抗体-IR700 缀合物接触后，几分钟内暴露于近红外光下的细胞会迅速肿胀、起泡，最终破裂。光诱导的配体释放反应还会导致抗体-IR700 缀合物的二聚化或聚集，立即丧失 IR700 荧光，从而可以实时监测 NIR-PIT 治疗。
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