• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

硅酞菁类近红外光免疫治疗（NIR-PIT）的细胞毒性的化学基础及其对治疗监测的意义。

The chemical basis of cytotoxicity of silicon-phthalocyanine-based near infrared photoimmunotherapy (NIR-PIT) and its implications for treatment monitoring.

机构信息

Molecular Imaging Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD, 20892-1088, United States.

Molecular Imaging Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD, 20892-1088, United States.

出版信息

Curr Opin Chem Biol. 2023 Jun;74:102289. doi: 10.1016/j.cbpa.2023.102289. Epub 2023 Mar 24.

DOI:10.1016/j.cbpa.2023.102289
PMID:36966701
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10225316/
Abstract

Near infrared photoimmunotherapy (NIR-PIT) is a new cancer therapy based on the photo-induced ligand release reaction of a silicon-phthalocyanine derivative, IRDye700DX (IR700), that causes rapid cell death. Following exposure to an antibody-IR700-conjugate, cells exposed to NIR light within minutes undergo rapid swelling, blebbing, and finally, bursting. The photo-induced ligand release reaction also induces immediate loss of IR700 fluorescence due to dimerization or aggregation of the antibody-IR700 conjugate allowing for real time monitoring of NIR-PIT therapy.

摘要

近红外光免疫治疗（NIR-PIT）是一种基于硅酞菁衍生物 IRDye700DX（IR700）光诱导配体释放反应的新型癌症治疗方法，可导致细胞迅速死亡。在与抗体-IR700 缀合物接触后，几分钟内暴露于近红外光下的细胞会迅速肿胀、起泡，最终破裂。光诱导的配体释放反应还会导致抗体-IR700 缀合物的二聚化或聚集，立即丧失 IR700 荧光，从而可以实时监测 NIR-PIT 治疗。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9923/10225316/d670eb7dfbdc/nihms-1879759-f0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9923/10225316/54f691e85df3/nihms-1879759-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9923/10225316/238b4d90e040/nihms-1879759-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9923/10225316/d670eb7dfbdc/nihms-1879759-f0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9923/10225316/54f691e85df3/nihms-1879759-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9923/10225316/238b4d90e040/nihms-1879759-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9923/10225316/d670eb7dfbdc/nihms-1879759-f0003.jpg

相似文献

1
The chemical basis of cytotoxicity of silicon-phthalocyanine-based near infrared photoimmunotherapy (NIR-PIT) and its implications for treatment monitoring.硅酞菁类近红外光免疫治疗（NIR-PIT）的细胞毒性的化学基础及其对治疗监测的意义。
Curr Opin Chem Biol. 2023 Jun;74:102289. doi: 10.1016/j.cbpa.2023.102289. Epub 2023 Mar 24.
2
Near-infrared photoimmunotherapy with galactosyl serum albumin in a model of diffuse peritoneal disseminated ovarian cancer.在弥漫性腹膜播散性卵巢癌模型中使用半乳糖基血清白蛋白进行近红外光免疫疗法。
Oncotarget. 2016 Nov 29;7(48):79408-79416. doi: 10.18632/oncotarget.12710.
3
Trastuzumab-based near-infrared photoimmunotherapy in xenograft mouse of breast cancer.曲妥珠单抗为基础的近红外光免疫治疗乳腺癌异种移植瘤模型的研究。
Cancer Med. 2023 Feb;12(4):4579-4589. doi: 10.1002/cam4.5302. Epub 2022 Oct 18.
4
Fluorescence Imaging of Tumor-Accumulating Antibody-IR700 Conjugates Prior to Near-Infrared Photoimmunotherapy (NIR-PIT) Using a Commercially Available Camera Designed for Indocyanine Green.利用一款市售的、专为近红外荧光染料（吲哚菁绿）设计的相机，在近红外光免疫治疗（NIR-PIT）前对肿瘤蓄积抗体-IR700 缀合物进行荧光成像。
Mol Pharm. 2021 Mar 1;18(3):1238-1246. doi: 10.1021/acs.molpharmaceut.0c01107. Epub 2021 Jan 27.
5
Comparison of low-molecular-weight ligand and whole antibody in prostate-specific membrane antigen targeted near-infrared photoimmunotherapy.低相对分子质量配体与全抗体在前列腺特异性膜抗原靶向近红外光免疫治疗中的比较。
Int J Pharm. 2021 Nov 20;609:121135. doi: 10.1016/j.ijpharm.2021.121135. Epub 2021 Sep 24.
6
[Near Infrared Photoimmunotherapy for Cancer].[癌症的近红外光免疫疗法]
Gan To Kagaku Ryoho. 2019 Jan;46(1):28-33.
7
Improved micro-distribution of antibody-photon absorber conjugates after initial near infrared photoimmunotherapy (NIR-PIT).初次近红外光免疫疗法（NIR-PIT）后抗体-光子吸收剂偶联物的微分布得到改善。
J Control Release. 2016 Jun 28;232:1-8. doi: 10.1016/j.jconrel.2016.04.003. Epub 2016 Apr 5.
8
Near-Infrared Photoimmunotherapy of Cancer.近红外光免疫治疗癌症。
Acc Chem Res. 2019 Aug 20;52(8):2332-2339. doi: 10.1021/acs.accounts.9b00273. Epub 2019 Jul 23.
9
Near Infrared Photoimmunotherapy Targeting EGFR Positive Triple Negative Breast Cancer: Optimizing the Conjugate-Light Regimen.靶向表皮生长因子受体阳性三阴性乳腺癌的近红外光免疫疗法：优化偶联物 - 光照方案
PLoS One. 2015 Aug 27;10(8):e0136829. doi: 10.1371/journal.pone.0136829. eCollection 2015.
10
Real-time monitoring of in vivo acute necrotic cancer cell death induced by near infrared photoimmunotherapy using fluorescence lifetime imaging.利用荧光寿命成像实时监测近红外光免疫治疗诱导的体内急性坏死性癌细胞死亡。
Cancer Res. 2012 Sep 15;72(18):4622-8. doi: 10.1158/0008-5472.CAN-12-1298. Epub 2012 Jul 16.

本文引用的文献

1
Real-time IR700 Fluorescence Imaging During Near-infrared Photoimmunotherapy Using a Clinically-approved Camera for Indocyanine Green.使用临床批准的吲哚菁绿相机在近红外光免疫治疗期间进行实时IR700荧光成像。
Cancer Diagn Progn. 2021 May 3;1(2):29-34. doi: 10.21873/cdp.10005. eCollection 2021 May-Jun.
2
Electron Donors Rather Than Reactive Oxygen Species Needed for Therapeutic Photochemical Reaction of Near-Infrared Photoimmunotherapy.近红外光免疫疗法治疗性光化学反应所需的是电子供体而非活性氧物种。
ACS Pharmacol Transl Sci. 2021 Sep 17;4(5):1689-1701. doi: 10.1021/acsptsci.1c00184. eCollection 2021 Oct 8.
3
Phase 1/2a, open-label, multicenter study of RM-1929 photoimmunotherapy in patients with locoregional, recurrent head and neck squamous cell carcinoma.RM-1929 光免疫疗法治疗局部复发性头颈部鳞状细胞癌患者的 1/2a 期、开放标签、多中心研究。
Head Neck. 2021 Dec;43(12):3875-3887. doi: 10.1002/hed.26885. Epub 2021 Oct 9.
4
Regulatory approval of photoimmunotherapy: photodynamic therapy that induces immunogenic cell death.光免疫疗法的监管批准：诱导免疫原性细胞死亡的光动力疗法。
Oncoimmunology. 2020 Oct 27;9(1):1841393. doi: 10.1080/2162402X.2020.1841393.
5
Theoretical and Experimental Studies on the Near-Infrared Photoreaction Mechanism of a Silicon Phthalocyanine Photoimmunotherapy Dye: Photoinduced Hydrolysis by Radical Anion Generation.硅酞菁光免疫治疗染料近红外光光化学反应机理的理论与实验研究：通过自由基阴离子生成引发光诱导水解。
Chempluschem. 2020 Sep;85(9):1959-1963. doi: 10.1002/cplu.202000338. Epub 2020 May 25.
6
Near-Infrared Photoimmunotherapy: Photoactivatable Antibody-Drug Conjugates (ADCs).近红外光免疫治疗：光活化抗体药物偶联物（ADC）。
Bioconjug Chem. 2020 Jan 15;31(1):28-36. doi: 10.1021/acs.bioconjchem.9b00546. Epub 2019 Sep 13.
7
Near-Infrared Photoimmunotherapy of Cancer.近红外光免疫治疗癌症。
Acc Chem Res. 2019 Aug 20;52(8):2332-2339. doi: 10.1021/acs.accounts.9b00273. Epub 2019 Jul 23.
8
Photoinduced Ligand Release from a Silicon Phthalocyanine Dye Conjugated with Monoclonal Antibodies: A Mechanism of Cancer Cell Cytotoxicity after Near-Infrared Photoimmunotherapy.与单克隆抗体偶联的硅酞菁染料的光诱导配体释放：近红外光免疫治疗后癌细胞细胞毒性的机制
ACS Cent Sci. 2018 Nov 28;4(11):1559-1569. doi: 10.1021/acscentsci.8b00565. Epub 2018 Nov 6.
9
Immunogenic cancer cell death selectively induced by near infrared photoimmunotherapy initiates host tumor immunity.近红外光免疫疗法选择性诱导的免疫原性癌细胞死亡引发宿主肿瘤免疫。
Oncotarget. 2017 Feb 7;8(6):10425-10436. doi: 10.18632/oncotarget.14425.
10
Cancer cell-selective in vivo near infrared photoimmunotherapy targeting specific membrane molecules.针对特定膜分子的肿瘤细胞选择性体内近红外光免疫治疗。
Nat Med. 2011 Nov 6;17(12):1685-91. doi: 10.1038/nm.2554.