Craig Sonya E L, Michalski Megan N, Williams Bart O
Department of Cell Biology, Van Andel Institute, Grand Rapids, MI, United States.
Department of Cell Biology, Van Andel Institute, Grand Rapids, MI, United States.
Curr Top Dev Biol. 2023;153:327-346. doi: 10.1016/bs.ctdb.2023.01.004. Epub 2023 Mar 7.
WNT signaling, essential for many aspects of development, is among the most commonly altered pathways associated with human disease. While initially studied in cancer, dysregulation of WNT signaling has been determined to be essential for skeletal development and the maintenance of bone health throughout life. In this review, we discuss the role of Wnt signaling in bone development and disease with a particular focus on two areas. First, we discuss the roles of WNT signaling pathways in skeletal development, with an emphasis on congenital and idiopathic skeletal syndromes and diseases that are associated with genetic variations in WNT signaling components. Next, we cover a topic that has long been an interest of our laboratory, how high and low levels of WNT signaling affects the establishment and maintenance of healthy bone mass. We conclude with a discussion of the status of WNT-based therapeutics in the treatment of skeletal disease.
WNT信号传导对发育的许多方面至关重要，是与人类疾病相关的最常发生改变的信号通路之一。虽然最初是在癌症研究中发现的，但现已确定WNT信号传导失调对骨骼发育以及一生当中骨骼健康的维持至关重要。在本综述中，我们将讨论Wnt信号传导在骨骼发育和疾病中的作用，特别关注两个领域。首先，我们将讨论WNT信号通路在骨骼发育中的作用，重点关注与WNT信号传导成分基因变异相关的先天性和特发性骨骼综合征及疾病。接下来，我们将探讨一个长期以来一直是我们实验室研究兴趣所在的话题，即WNT信号的高低水平如何影响健康骨量的建立和维持。最后，我们将讨论基于WNT的疗法在治疗骨骼疾病方面的现状。
