Center for Epigenetics and Disease Prevention, Institute of Biosciences and Technology, Texas A&M University, Houston, TX, USA.
Center for Epigenetics and Disease Prevention, Institute of Biosciences and Technology, Texas A&M University, Houston, TX, USA.
Trends Cancer. 2023 Jun;9(6):459-460. doi: 10.1016/j.trecan.2023.03.006. Epub 2023 Mar 25.
Two recent studies published in Nature by Karimi et al. and Sorin et al. applied multiplexed imaging mass cytometry (IMC) to characterize the single-cell tumor immune landscapes covering millions of cells in brain tumors and lung adenocarcinomas (LUAD). They identified specific cell subtypes and cell-cell interactions that correlate with distinct clinical outcomes, thus providing valuable insights into tumor biology and prognostic prediction based on spatial architecture.
最近，Karimi 等人和 Sorin 等人在《自然》杂志上发表了两项研究，他们应用多重成像质谱细胞术（IMC）来描绘覆盖脑肿瘤和肺腺癌（LUAD）中数百万个细胞的单细胞肿瘤免疫图谱。他们鉴定出与不同临床结果相关的特定细胞亚型和细胞-细胞相互作用，从而为基于空间结构的肿瘤生物学和预后预测提供了有价值的见解。
