• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

苯巴比妥治疗阿片类药物流行背景下的酒精戒断：一个被忽视的警告。

Phenobarbital for alcohol withdrawal in the context of the opioid epidemic: a neglected caveat.

机构信息

Department of Behavioral Health, Denver Health and Hospital Authority, Denver, CO, USA.

Addiction Medicine Fellowship, University of Colorado School of Medicine, Aurora, CO, USA.

出版信息

Addiction. 2023 Jul;118(7):1198-1200. doi: 10.1111/add.16194. Epub 2023 Apr 10.

DOI:10.1111/add.16194
PMID:36967706
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10881280/
Abstract

Phenobarbital interacts with the mortality-reducing opioid agonist therapies buprenorphine and methadone, risking delayed opioid withdrawal and relapse when administered concurrently. With increased adoption of phenobarbital into alcohol withdrawal protocols there should be safeguards in place to—in most cases—avoid phenobarbital for patients with a concurrent opioid use disorder.

摘要

苯巴比妥会与具有降低死亡率的阿片类激动剂美沙酮和丁丙诺啡相互作用，如果同时使用，可能会导致阿片类药物戒断延迟和复发。随着苯巴比妥在酒精戒断方案中的应用增加，应该采取保障措施——在大多数情况下——避免对同时患有阿片类药物使用障碍的患者使用苯巴比妥。

相似文献

1
Phenobarbital for alcohol withdrawal in the context of the opioid epidemic: a neglected caveat.苯巴比妥治疗阿片类药物流行背景下的酒精戒断：一个被忽视的警告。
Addiction. 2023 Jul;118(7):1198-1200. doi: 10.1111/add.16194. Epub 2023 Apr 10.
2
Transition From Methadone to Buprenorphine Using a Short-acting Agonist Bridge in the Inpatient Setting: A Case Study.在住院环境中使用短效激动剂桥从美沙酮过渡到丁丙诺啡：案例研究。
J Addict Med. 2020 Sep/Oct;14(5):e274-e276. doi: 10.1097/ADM.0000000000000623.
3
"Should I stay or should I go?" Coming off methadone and buprenorphine treatment.“我是该留下还是离开？”——美沙酮和丁丙诺啡戒毒治疗的停药期。
Int J Drug Policy. 2011 Jan;22(1):77-81. doi: 10.1016/j.drugpo.2010.08.001. Epub 2010 Oct 16.
4
Neonatal opioid withdrawal syndrome.新生儿阿片类戒断综合征。
Obstet Gynecol Clin North Am. 2014 Jun;41(2):317-34. doi: 10.1016/j.ogc.2014.02.010.
5
Treatment of Opioid-Use Disorders.阿片类物质使用障碍的治疗
N Engl J Med. 2016 Jul 28;375(4):357-68. doi: 10.1056/NEJMra1604339.
6
Use and misuse of opioid agonists in opioid addiction.阿片类药物成瘾中阿片类激动剂的使用和滥用。
Cleve Clin J Med. 2017 May;84(5):377-384. doi: 10.3949/ccjm.84a.16091.
7
Adjunctive memantine for opioid use disorder treatment: A systematic review.辅助美金刚治疗阿片类药物使用障碍：系统评价。
J Subst Abuse Treat. 2019 Dec;107:38-43. doi: 10.1016/j.jsat.2019.10.003. Epub 2019 Oct 20.
8
Pharmacotherapy for Substance Use Disorders.物质使用障碍的药物治疗
Med Clin North Am. 2016 Jul;100(4):891-910. doi: 10.1016/j.mcna.2016.03.011. Epub 2016 Apr 20.
9
Switch from methadone to buprenorphine with microinduction in outpatient setting.门诊环境下米非司酮转为丁丙诺啡微诱导。
Tidsskr Nor Laegeforen. 2024 Sep 5;144(10). doi: 10.4045/tidsskr.24.0073. Print 2024 Sep 10.
10
Comparison of buprenorphine and methadone in the treatment of opiate withdrawal: possible advantages of buprenorphine for the treatment of opiate-benzodiazepine codependent patients?丁丙诺啡与美沙酮治疗阿片类戒断反应的比较：丁丙诺啡治疗阿片类 - 苯二氮䓬类药物依赖患者的潜在优势？
J Clin Psychopharmacol. 2007 Apr;27(2):188-92. doi: 10.1097/JCP.0b013e318032ec2a.

本文引用的文献

1
Phenobarbital for Severe Alcohol Withdrawal Syndrome: A Multicenter Retrospective Cohort Study.苯巴比妥用于严重酒精戒断综合征：一项多中心回顾性队列研究。
Am J Respir Crit Care Med. 2022 Nov 1;206(9):1171-1174. doi: 10.1164/rccm.202203-0466LE.
2
Phenobarbital and/or benzodiazepines for recurrent alcohol withdrawal: A self-controlled, retrospective cohort study.苯巴比妥和/或苯二氮䓬类药物治疗复发性酒精戒断：一项自身对照、回顾性队列研究。
Am J Emerg Med. 2022 Apr;54:263-266. doi: 10.1016/j.ajem.2022.02.020. Epub 2022 Feb 19.
3
Managing the opioid crisis in North America and beyond.应对北美及其他地区的阿片类药物危机。
Lancet. 2022 Feb 5;399(10324):495. doi: 10.1016/S0140-6736(22)00200-8. Epub 2022 Feb 2.
4
Association of Opioid Agonist Treatment With All-Cause Mortality and Specific Causes of Death Among People With Opioid Dependence: A Systematic Review and Meta-analysis.阿片类激动剂治疗与阿片类药物依赖患者全因死亡率及特定死因的相关性：系统评价和荟萃分析。
JAMA Psychiatry. 2021 Sep 1;78(9):979-993. doi: 10.1001/jamapsychiatry.2021.0976.
5
Adjunctive Phenobarbital for Alcohol Withdrawal Syndrome: A Focused Literature Review.辅助性苯巴比妥治疗酒精戒断综合征：重点文献回顾。
Ann Pharmacother. 2021 Dec;55(12):1515-1524. doi: 10.1177/1060028021999821. Epub 2021 Mar 7.
6
Concerns Regarding the Use of Phenobarbital for Alcohol Withdrawal Management.关于使用苯巴比妥进行酒精戒断管理的担忧。
Psychosomatics. 2020 Nov-Dec;61(6):861-863. doi: 10.1016/j.psym.2020.04.006. Epub 2020 Apr 18.
7
Phenobarbital and symptom-triggered lorazepam versus lorazepam alone for severe alcohol withdrawal in the intensive care unit.苯巴比妥和症状触发的劳拉西泮与单独使用劳拉西泮治疗重症监护病房严重酒精戒断。
Alcohol. 2020 Feb;82:23-27. doi: 10.1016/j.alcohol.2019.07.004. Epub 2019 Jul 18.
8
Benzodiazepines vs barbiturates for alcohol withdrawal: Analysis of 3 different treatment protocols.苯二氮䓬类药物与巴比妥类药物治疗酒精戒断：3 种不同治疗方案的分析。
Am J Emerg Med. 2019 Apr;37(4):733-736. doi: 10.1016/j.ajem.2019.01.002. Epub 2019 Jan 3.
9
Phenobarbital for acute alcohol withdrawal: a prospective randomized double-blind placebo-controlled study.苯巴比妥用于急性酒精戒断：一项前瞻性随机双盲安慰剂对照研究。
J Emerg Med. 2013 Mar;44(3):592-598.e2. doi: 10.1016/j.jemermed.2012.07.056. Epub 2012 Sep 19.
10
Safety and effectiveness of a fixed-dose phenobarbital protocol for inpatient benzodiazepine detoxification.苯二氮䓬类药物住院解毒固定剂量苯巴比妥方案的安全性和有效性。
J Subst Abuse Treat. 2012 Oct;43(3):331-4. doi: 10.1016/j.jsat.2011.12.011. Epub 2012 Jan 28.