苯巴比妥治疗阿片类药物流行背景下的酒精戒断：一个被忽视的警告。
Phenobarbital for alcohol withdrawal in the context of the opioid epidemic: a neglected caveat.
机构信息
Department of Behavioral Health, Denver Health and Hospital Authority, Denver, CO, USA.
Addiction Medicine Fellowship, University of Colorado School of Medicine, Aurora, CO, USA.
出版信息
Addiction. 2023 Jul;118(7):1198-1200. doi: 10.1111/add.16194. Epub 2023 Apr 10.
Abstract
Phenobarbital interacts with the mortality-reducing opioid agonist therapies buprenorphine and methadone, risking delayed opioid withdrawal and relapse when administered concurrently. With increased adoption of phenobarbital into alcohol withdrawal protocols there should be safeguards in place to—in most cases—avoid phenobarbital for patients with a concurrent opioid use disorder.
摘要
苯巴比妥会与具有降低死亡率的阿片类激动剂美沙酮和丁丙诺啡相互作用，如果同时使用，可能会导致阿片类药物戒断延迟和复发。随着苯巴比妥在酒精戒断方案中的应用增加，应该采取保障措施——在大多数情况下——避免对同时患有阿片类药物使用障碍的患者使用苯巴比妥。
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