Smith G, Grenfell B T, Anderson R M, Beddington J
Department of Pure and Applied Biology, Imperial College, London University.
Parasitology. 1987 Oct;95 ( Pt 2):407-20. doi: 10.1017/s0031182000057838.
Five chemoprophylactic or chemotherapeutic strategies against bovine ostertagiasis are compared using a mathematical model of the population biology of Ostertagia ostertagi. The model offers a means of screening novel strategies prior to their further investigation in the field. Under conditions of climate and management typical of many regions in Northern temperate Europe, the model indicates that all of the tested prophylactic strategies will result in a profound reduction in the intensity of infection in grazing beef calves when compared with an untreated control group or the simple therapeutic protocol. Not all of those strategies which caused diminution in the scale of the midsummer rise in pasture larval contamination resulted in progressively less contaminated pastures in subsequent years. Moreover, the reproductive potential of the parasite is so great that the principal advantage of the 'pasture cleaning' effect that is the consequence of some protocols is not that the pasture may eventually be used to graze untreated calves but that the treated animals are subjected to a progressively smaller parasitic challenge with the concomitant pay-off in production gains.
利用奥斯特他线虫种群生物学的数学模型，比较了针对牛奥斯特他线虫病的五种化学预防或化学治疗策略。该模型提供了一种在新策略进行实地进一步研究之前进行筛选的方法。在北欧许多地区典型的气候和管理条件下，该模型表明，与未处理的对照组或简单的治疗方案相比，所有测试的预防策略都将导致放牧肉牛犊感染强度大幅降低。并非所有导致仲夏时节牧场幼虫污染规模减小的策略都会使后续年份的牧场污染程度逐渐降低。此外，寄生虫的繁殖潜力非常大，某些方案所带来的“牧场清洁”效果的主要优势不在于最终可以用该牧场放牧未处理的牛犊，而在于接受治疗的动物所面临的寄生虫挑战会逐渐减小，从而带来生产效益的相应提升。
