电子顺磁共振波谱揭示的提高铜配合物对转移性黑色素瘤细胞细胞毒性的新策略。
A new strategy for improving cytotoxicity of a copper complex toward metastatic melanoma cells unveiled by EPR spectroscopy.
作者信息
Vieira Eduardo Guimarães, Fazzi Rodrigo Boni, Martins Daniel O T A, Sheveleva Alena M, Tuna Floriana, da Costa Ferreira Ana Maria
机构信息
Department of Fundamental Chemistry, Institute of Chemistry, University of São Paulo 05508-000 São Paulo-SP Brazil
EPSRC National EPR Facility, Department of Chemistry and Photon Science Institute, University of Manchester Manchester M13 9PL UK
出版信息
RSC Adv. 2023 Mar 24;13(14):9715-9719. doi: 10.1039/d2ra07266a. eCollection 2023 Mar 20.
A novel strategy of improving cytotoxicity against metastatic melanoma cells using an oxindolimine copper(ii) complex immobilized and dimerized on a modified Polyhedral Oligomeric Silsesquioxane (POSS) matrix was developed, as revealed by electron paramagnetic resonance (EPR) spectroscopy. An assured correlation between continuous-wave (CW) and pulsed EPR spectroscopies provided a complete characterization of the actual active species, its coordination environment, as well as the efficiency/selectivity of the bioconjugate materials.
电子顺磁共振（EPR）光谱显示，一种新的策略被开发出来，即使用固定在改性多面体低聚倍半硅氧烷（POSS）基质上并二聚化的氧化吲哚铜（II）配合物来提高对转移性黑色素瘤细胞的细胞毒性。连续波（CW）和脉冲EPR光谱之间确定的相关性提供了对实际活性物种、其配位环境以及生物共轭材料的效率/选择性的完整表征。
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