铁死亡在妊娠相关疾病中的作用及其治疗潜力。

Xu Jinfeng, Zhou Fan, Wang Xiaodong, Mo Chunheng

Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu, China.

West China School of Medicine, Sichuan University, Chengdu, China.

Front Cell Dev Biol. 2023 Mar 8;11:1083838. doi: 10.3389/fcell.2023.1083838. eCollection 2023.

Ferroptosis is a form of regulated cell death characterized by iron overload, overwhelming lipid peroxidation, and disruption of antioxidant systems. Emerging evidence suggests that ferroptosis is associated with pregnancy related diseases, such as spontaneous abortion, pre-eclampsia, gestational diabetes mellitus, intrahepatic cholestasis of pregnancy, and spontaneous preterm birth. According to these findings, inhibiting ferroptosis might be a potential option to treat pregnancy related diseases. This review summarizes the mechanisms and advances of ferroptosis, the pathogenic role of ferroptosis in pregnancy related diseases and the potential medicines for its treatment.

铁死亡是一种程序性细胞死亡形式，其特征为铁过载、脂质过氧化加剧以及抗氧化系统破坏。新出现的证据表明，铁死亡与妊娠相关疾病有关，如自然流产、子痫前期、妊娠期糖尿病、妊娠肝内胆汁淤积症和自然早产。根据这些发现，抑制铁死亡可能是治疗妊娠相关疾病的一个潜在选择。本综述总结了铁死亡的机制和研究进展、铁死亡在妊娠相关疾病中的致病作用及其潜在治疗药物。