Chen Zhixian, Gan Jianfeng, Zhang Mo, Du Yan, Zhao Hongbo
Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Obstetrics and Gynecology Hospital, Fudan University, Shanghai 200011, China.
Department of Obstetrics and Gynecology of Shanghai Medical School, Fudan University, Shanghai 200032, China.
Antioxidants (Basel). 2022 Jun 28;11(7):1282. doi: 10.3390/antiox11071282.
Iron is essential for cell survival, and iron deficiency is a known risk factor for many reproductive diseases. Paradoxically, such disorders are also more common in cases of iron overload. Here, we evaluated the role of ferroptosis in women's health, particularly focusing on pre-eclampsia (PE). PE is a multisystem disorder and is one of the leading causes of maternal and perinatal morbidity and mortality, especially when the condition is of early onset. Nevertheless, the exact etiological mechanism of PE remains unclear. Interestingly, ferroptosis, as a regulated iron-dependent cell death pathway, involves a lethal accumulation of lipid peroxides and shares some characteristics with PE pathophysiology. In this review, we comprehensively reviewed and summarized recent studies investigating the molecular mechanisms involved in the regulation and execution of ferroptosis, as well as ferroptosis mechanisms in the pathology of PE. We propose that ferroptosis not only plays an important role in PE, but may also become a novel therapeutic target for PE.
铁对于细胞存活至关重要，而缺铁是许多生殖疾病的已知风险因素。矛盾的是，这些疾病在铁过载的情况下也更为常见。在此，我们评估了铁死亡在女性健康中的作用，尤其关注子痫前期（PE）。PE是一种多系统疾病，是孕产妇和围产期发病及死亡的主要原因之一，尤其是早发型病例。然而，PE的确切病因机制仍不清楚。有趣的是，铁死亡作为一种受调控的铁依赖性细胞死亡途径，涉及脂质过氧化物的致死性积累，并且与PE的病理生理学有一些共同特征。在本综述中，我们全面回顾并总结了最近关于铁死亡调控和执行所涉及的分子机制以及PE病理学中铁死亡机制的研究。我们提出，铁死亡不仅在PE中起重要作用，还可能成为PE的一个新的治疗靶点。
