Meirovitch J, Kitai-Cohen Y, Keren G, Fiendler G, Rubinstein E
Department of Pediatrics, Chaim Sheba Medical Center, Tel-Hashomer, Israel.
Pediatr Infect Dis J. 1987 Oct;6(10):921-4. doi: 10.1097/00006454-198710000-00013.
Forty-six episodes of cerebrospinal fluid shunt infections developed in 32 patients undergoing cerebrospinal fluid shunt operations during a 13-year period (1972 to 1984). The infection rate was 21%/operative procedure and 33%/patient. The shunt infection rate in revisions of infected shunts was 52%, a rate significantly larger than that in revisions of noninfected shunts (11%). Eight patients (25%) of the initially infected patients had more than one infectious episode. Predominating pathogens in patients who had shunt revisions included coagulase-negative staphylococci in 8 of 15 episodes (4 patients). Coagulase-negative staphylococci accounted for 28% and coagulase-positive staphylococci for 14% of the initial infectious episodes. Risk factors for development of shunt infection included age younger than 3 years, a previously infected shunt and surgery to revise the infected shunt. Therapy of infected shunts with antibiotics alone or with antibiotics plus an operative shunt revision resulted in similar success rates.
在13年期间（1972年至1984年），32例接受脑脊液分流手术的患者发生了46次脑脊液分流感染。感染率为21%/手术操作和33%/患者。感染分流器修复手术中的分流感染率为52%，显著高于未感染分流器修复手术中的感染率（11%）。最初感染的患者中有8例（25%）发生了不止一次感染发作。接受分流器修复手术的患者中，主要病原体包括凝固酶阴性葡萄球菌，在15次发作中有8次（4例患者）。凝固酶阴性葡萄球菌占初始感染发作的28%，凝固酶阳性葡萄球菌占14%。分流感染发生的危险因素包括年龄小于3岁、既往感染的分流器以及感染分流器的修复手术。单纯使用抗生素或抗生素加手术修复感染分流器的治疗成功率相似。
