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Smoking-Related DNA Alkylation Events Are Mapped at Single-Nucleotide Resolution.

作者信息

Huang Alvin T, Tang Weixin

机构信息

Department of Chemistry, The University of Chicago, Chicago, Illinois 60637, United States.

Institute for Biophysical Dynamics, The University of Chicago, Chicago, Illinois 60637, United States.

出版信息

ACS Cent Sci. 2023 Mar 7;9(3):346-348. doi: 10.1021/acscentsci.3c00246. eCollection 2023 Mar 22.

DOI:10.1021/acscentsci.3c00246
PMID:36968536
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10037440/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e87b/10037440/76d05b1be0f8/oc3c00246_0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e87b/10037440/76d05b1be0f8/oc3c00246_0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e87b/10037440/76d05b1be0f8/oc3c00246_0001.jpg

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本文引用的文献

1
Quantification and Mapping of Alkylation in the Human Genome Reveal Single Nucleotide Resolution Precursors of Mutational Signatures.人类基因组中烷基化的定量与图谱分析揭示了突变特征的单核苷酸分辨率前体。
ACS Cent Sci. 2023 Feb 22;9(3):362-372. doi: 10.1021/acscentsci.2c01100. eCollection 2023 Mar 22.
2
Endogenous DNA Damage as a Source of Genomic Instability in Cancer.内源性DNA损伤作为癌症基因组不稳定的一个来源。
Cell. 2017 Feb 9;168(4):644-656. doi: 10.1016/j.cell.2017.01.002.
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Mutational signatures associated with tobacco smoking in human cancer.
人类癌症中与吸烟相关的突变特征。
Science. 2016 Nov 4;354(6312):618-622. doi: 10.1126/science.aag0299.
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DNA adducts from a tumorigenic metabolite of benzo[a]pyrene block human RNA polymerase II elongation in a sequence- and stereochemistry-dependent manner.来自苯并[a]芘致瘤代谢物的DNA加合物以序列和立体化学依赖性方式阻断人类RNA聚合酶II的延伸。
J Mol Biol. 2002 Aug 2;321(1):29-47. doi: 10.1016/s0022-2836(02)00593-4.
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Strand-break formation in DNA modified by benzo[alpha]pyrene diolepoxide. Quantitative cleavage by Escherichia coli uvrABC endonuclease.苯并[a]芘二环氧物修饰的DNA中的链断裂形成。大肠杆菌uvrABC核酸内切酶的定量切割。
Mutat Res. 1983 Jun;112(3):139-45. doi: 10.1016/0167-8817(83)90036-6.
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Metabolic activation of benzo(a)pyrene proceeds by a diol-epoxide.苯并(a)芘的代谢活化通过二醇环氧化物进行。
Nature. 1974 Nov 22;252(5481):326-8. doi: 10.1038/252326a0.
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Covalent bonding of bay-region diol epoxides to nucleic acids.湾区二醇环氧化物与核酸的共价键合。
Adv Exp Med Biol. 1991;283:533-53. doi: 10.1007/978-1-4684-5877-0_70.
8
Metabolism of benzo(a)pyrene and benzo (a)pyrene derivatives to mutagenic products by highly purified hepatic microsomal enzymes.通过高度纯化的肝微粒体酶将苯并(a)芘和苯并(a)芘衍生物代谢为致突变产物。
J Biol Chem. 1976 Aug 25;251(16):4882-90.