在三代人中建立认知基线：弗雷明汉心脏研究。
Establishing cognitive baseline in three generations: Framingham Heart Study.
作者信息
Yang Jin, Ang Ting Fang Alvin, Lu Sophia, Liu Xue, Devine Sherral, Au Rhoda, Liu Chunyu
机构信息
Department for Endemic Disease Control and Prevention Henan Provincial Center for Disease Control and Prevention Zhengzhou China.
Department of Anatomy and Neurobiology Boston University School of Medicine Boston Massachusetts USA.
出版信息
Alzheimers Dement (Amst). 2023 Mar 24;15(1):e12416. doi: 10.1002/dad2.12416. eCollection 2023 Jan-Mar.
INTRODUCTION
Generational changes warrant recalibrating normative cognitive measures to detect changes indicative of dementia risk within each generation.
METHODS
We performed linear regressions to compare eight neuropsychological (NP) tests among three-generation cohorts at baseline in Framingham Heart Study (FHS, = 4787) and conducted Cox regressions to investigate the relationships of NP tests with generation-specific dementia risk.
RESULTS
The FHS second and third generations performed better than the first generation for seven NP tests (0.14-0.81 standard deviation improvement, ≤ .001) while the second and third generations performed similarly for six of eight NP tests ( > .05). One standard deviation better performance was associated with a higher reduction in incident dementia risk in the second than the first generation (35% vs. 24%, = .02) for the similarities test.
DISCUSSION
Our findings suggest cohort-based norms are needed for cognitive assessment for the diagnosis of cognitive impairment and dementia.
引言
代际变化需要重新校准规范性认知测量方法，以检测每代人中表明痴呆风险的变化。
方法
我们进行线性回归，以比较弗雷明汉心脏研究（FHS，n = 4787）中三代队列在基线时的八项神经心理学（NP）测试，并进行Cox回归以研究NP测试与特定代际痴呆风险之间的关系。
结果
FHS第二代和第三代在七项NP测试中的表现优于第一代（改善0.14 - 0.81标准差，P≤.001），而第二代和第三代在八项NP测试中的六项表现相似（P>.05）。对于相似性测试，比第一代表现好一个标准差与第二代发生痴呆风险的降低幅度更高相关（35%对24%，P =.02）。
讨论
我们的研究结果表明，在认知评估以诊断认知障碍和痴呆时需要基于队列的规范。
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