• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

侵袭性葡萄胎酷似异常子宫出血:一例报告

Invasive Mole Mimicking Abnormal Uterine Bleeding: A Case Report.

作者信息

Sankhe Darshan D, Somalwar Savita, Jiandani Farah, Jain Sheela, Shetty Anushree

机构信息

Department of Obstetrics and Gynaecology, Narendra Kumar Prasadrao (NKP) Salve Institute of Medical Sciences and Research Centre, Nagpur, IND.

出版信息

Cureus. 2023 Feb 19;15(2):e35195. doi: 10.7759/cureus.35195. eCollection 2023 Feb.

DOI:10.7759/cureus.35195
PMID:36968909
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10032175/
Abstract

Invasive mole (IM) is a very uncommon subtype of gestational trophoblastic disease (GTD), which is the invasion of molar tissue into the uterine or myometrial vasculature. However, this report presents a rare case of a 41-year-old female multiparous P7 with five full-term normal vaginal deliveries and two preterm normal vaginal deliveries. As the patient was not using contraception, her urine pregnancy test (UPT) was done, which demonstrated positive results. A speculum examination revealed a healthy cervix with just mild bleeding, whereas a vaginal examination revealed a firm cervix and an anteverted and mobile eight-week-old uterus along with a free fornix. Pelvic ultrasound and magnetic resonance imaging (MRI) demonstrated the diagnosis of GTD, for which consultation from an oncology physician was taken and the treatment proceeded with a total abdominal hysterectomy. Histological examination of the uterus showed a circumscribed nodule showing a large area of hemorrhage with few chorionic villi lined with trophoblastic cells and occasional villi invading the myometrium and endometrial cavity suggesting hydatidiform mole showing early invasion that confirmed the diagnosis of IM. In conclusion, reproductive-age women who experience abnormal uterine bleeding (AUB) should suspect pregnancy with several possible complications, for which a pregnancy test should be done to rule out complications.

摘要

侵袭性葡萄胎(IM)是妊娠滋养细胞疾病(GTD)中一种非常罕见的亚型,是指葡萄胎组织侵入子宫或肌层血管。然而,本报告介绍了一例罕见病例,患者为41岁经产妇,孕7产,有5次足月正常阴道分娩和2次早产正常阴道分娩。由于患者未采取避孕措施,进行了尿妊娠试验(UPT),结果呈阳性。窥器检查显示宫颈健康,仅有轻度出血,而阴道检查显示宫颈坚硬,子宫前倾且可活动,妊娠8周大小,穹窿部无异常。盆腔超声和磁共振成像(MRI)确诊为GTD,为此咨询了肿瘤内科医生,并进行了全腹子宫切除术。子宫组织学检查显示有一个边界清楚的结节,有大面积出血,有少量绒毛膜绒毛,衬有滋养层细胞,偶尔有绒毛侵入肌层和子宫内膜腔,提示葡萄胎早期侵袭,确诊为侵袭性葡萄胎。总之,出现异常子宫出血(AUB)的育龄妇女应怀疑妊娠并伴有多种可能的并发症,为此应进行妊娠试验以排除并发症。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9803/10032175/e586cb1adb66/cureus-0015-00000035195-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9803/10032175/7b2ed860c58e/cureus-0015-00000035195-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9803/10032175/13a31712cc63/cureus-0015-00000035195-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9803/10032175/e586cb1adb66/cureus-0015-00000035195-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9803/10032175/7b2ed860c58e/cureus-0015-00000035195-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9803/10032175/13a31712cc63/cureus-0015-00000035195-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9803/10032175/e586cb1adb66/cureus-0015-00000035195-i03.jpg

相似文献

1
Invasive Mole Mimicking Abnormal Uterine Bleeding: A Case Report.侵袭性葡萄胎酷似异常子宫出血:一例报告
Cureus. 2023 Feb 19;15(2):e35195. doi: 10.7759/cureus.35195. eCollection 2023 Feb.
2
Multiple metastatic gestational trophoblastic disease after a twin pregnancy with complete hydatidiform mole and coexisting fetus, following assisted reproductive technology: Case report and literature review.辅助生殖技术后双胎妊娠合并完全性葡萄胎及共存胎儿发生的多发性转移性妊娠滋养细胞疾病:病例报告及文献复习
Taiwan J Obstet Gynecol. 2018 Aug;57(4):588-593. doi: 10.1016/j.tjog.2018.06.020.
3
Gestational trophoblastic neoplasia mimicking ruptured ectopic pregnancy: A case report.妊娠滋养细胞肿瘤误诊为破裂型异位妊娠 1 例报告
Medicine (Baltimore). 2023 Jun 2;102(22):e33947. doi: 10.1097/MD.0000000000033947.
4
Complete molar pregnancy in postmenopausal women.绝经后妇女的完全性葡萄胎
J Midlife Health. 2016 Apr-Jun;7(2):91-3. doi: 10.4103/0976-7800.185328.
5
Gestational trophoblastic diseases - clinical guidelines for diagnosis, treatment, follow-up, and counselling.妊娠滋养细胞疾病——诊断、治疗、随访及咨询临床指南
Dan Med J. 2015 Nov;62(11):A5082.
6
Invasive mole with lung metastasis after an abdominal complete hydatidiform mole treatment.腹部完全性葡萄胎治疗后发生肺转移的侵袭性葡萄胎。
J Obstet Gynaecol Res. 2021 Jan;47(1):420-424. doi: 10.1111/jog.14537. Epub 2020 Oct 20.
7
Advances in diagnostics and management of gestational trophoblastic disease.妊娠滋养细胞疾病的诊断和治疗进展。
Radiol Oncol. 2022 Oct 27;56(4):430-439. doi: 10.2478/raon-2022-0038. eCollection 2022 Dec 1.
8
Partial hydatidiform mole with false-negative urine human chorionic gonadatropin test in the emergency department.急诊科尿人绒毛膜促性腺激素检测假阴性的部分性葡萄胎
J Emerg Med. 2014 Mar;46(3):348-50. doi: 10.1016/j.jemermed.2013.08.053. Epub 2013 Nov 1.
9
Postmenopausal complete hydatidiform mole: a case report.绝经后完全性葡萄胎:一例报告
Maturitas. 2008 Jan 20;59(1):95-8. doi: 10.1016/j.maturitas.2007.10.005. Epub 2007 Dec 26.
10
A hydatidiform mole in a postmenopausal woman. A case report and review of the literature.
Arch Pathol Lab Med. 2004 Sep;128(9):1039-42. doi: 10.5858/2004-128-1039-AHMIAP.

引用本文的文献

1
Chemotherapy-resistant invasive mole following partial hydatidiform molar pregnancy necessitating hysterectomy for hemorrhagic complications: A rare case report.部分性葡萄胎妊娠后化疗耐药性侵袭性葡萄胎因出血并发症需行子宫切除术:一例罕见病例报告
Int J Surg Case Rep. 2025 Aug;133:111577. doi: 10.1016/j.ijscr.2025.111577. Epub 2025 Jun 27.

本文引用的文献

1
Unusual Presentation of Invasive Mole: A Case Report.侵袭性葡萄胎的不典型表现:一例报告
J Reprod Infertil. 2017 Jan-Mar;18(1):205-209.
2
Update on the diagnosis and management of gestational trophoblastic disease.妊娠滋养细胞疾病的诊断与管理进展
Int J Gynaecol Obstet. 2015 Oct;131 Suppl 2:S123-6. doi: 10.1016/j.ijgo.2015.06.008.
3
Invasive mole of the uterus- a rare case diagnosed by ultrasound: a case report.子宫侵袭性葡萄胎——一例经超声诊断的罕见病例:病例报告
Med Ultrason. 2014 Jun;16(2):175-8. doi: 10.11152/mu.201.3.2066.162.hak1.
4
The role of surgery in the management of gestational trophoblastic neoplasia.手术在妊娠滋养细胞肿瘤治疗中的作用。
Obstet Gynecol Surv. 2013 Jul;68(7):533-42. doi: 10.1097/OGX.0b013e31829a82df.
5
Atlas of genetics and cytogenetics in oncology and haematology in 2013.2013 年肿瘤学和血液学的遗传学和细胞遗传学图谱。
Nucleic Acids Res. 2013 Jan;41(Database issue):D920-4. doi: 10.1093/nar/gks1082. Epub 2012 Nov 17.
6
Role of adjuvant hysterectomy in management of high-risk gestational trophoblastic neoplasia.辅助性子宫切除术在高危妊娠滋养细胞肿瘤治疗中的作用。
Int J Gynecol Cancer. 2012 Mar;22(3):509-14. doi: 10.1097/IGC.0b013e31823f88e2.
7
Gestational trophoblastic disease I: epidemiology, pathology, clinical presentation and diagnosis of gestational trophoblastic disease, and management of hydatidiform mole.妊娠滋养细胞疾病 I:流行病学、病理学、临床表现和诊断、葡萄胎的处理。
Am J Obstet Gynecol. 2010 Dec;203(6):531-9. doi: 10.1016/j.ajog.2010.06.073. Epub 2010 Aug 21.
8
Prevention of postmolar gestational trophoblastic neoplasia using prophylactic single bolus dose of actinomycin D in high-risk hydatidiform mole: a simple, effective, secure and low-cost approach without adverse effects on compliance to general follow-up or subsequent treatment.在高危葡萄胎中使用单次大剂量放线菌素D预防磨牙后妊娠滋养细胞肿瘤:一种简单、有效、安全且低成本的方法,对总体随访依从性或后续治疗无不良影响。
Gynecol Oncol. 2009 Aug;114(2):299-305. doi: 10.1016/j.ygyno.2009.04.006. Epub 2009 May 8.
9
The pathology of gestational trophoblastic disease: recent advances.妊娠滋养细胞疾病的病理学:最新进展
Pathology. 2007 Feb;39(1):88-96. doi: 10.1080/00313020601137367.
10
Sonographic and Doppler imaging in the diagnosis and treatment of gestational trophoblastic disease: a 12-year experience.超声及多普勒成像在妊娠滋养细胞疾病诊断与治疗中的应用:12年经验
J Ultrasound Med. 2005 Jan;24(1):15-24. doi: 10.7863/jum.2005.24.1.15.