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2013 年肿瘤学和血液学的遗传学和细胞遗传学图谱。

Atlas of genetics and cytogenetics in oncology and haematology in 2013.

机构信息

'Atlas in Poitiers Editorial Group', University and Hospital of Poitiers, INSERM U 935, 86021 Poitiers, France.

出版信息

Nucleic Acids Res. 2013 Jan;41(Database issue):D920-4. doi: 10.1093/nar/gks1082. Epub 2012 Nov 17.

Abstract

The Atlas of Genetics and Cytogenetics in Oncology and Haematology (http://AtlasGeneticsOncology.org) is a peer-reviewed internet journal/encyclopaedia/database focused on genes implicated in cancer, cytogenetics and clinical entities in cancer and cancer-prone hereditary diseases. The main goal of the Atlas is to provide review articles that describe complementary topics, namely, genes, genetic abnormalities, histopathology, clinical diagnoses and a large iconography. This description, which was historically based on karyotypic abnormalities and in situ hybridization (fluorescence in situ hybridization) techniques, now benefits from comparative genomic hybridization and massive sequencing, uncovering a tremendous amount of genetic rearrangements. As the Atlas combines different types of information (genes, genetic abnormalities, histopathology, clinical diagnoses and external links), its content is currently unique. The Atlas is a cognitive tool for fundamental and clinical research and has developed into an encyclopaedic work. In clinical practice, it contributes to the cytogenetic diagnosis and may guide treatment decision making, particularly regarding rare diseases (because they are numerous and are frequently encountered). Readers as well as the authors of the Atlas are researchers and/or clinicians.

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