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本文引用的文献

1
Anesthetic management of a patient with type 1 neurofibromatosis and an occult pheochromocytoma: a case report.1型神经纤维瘤病合并隐匿性嗜铬细胞瘤患者的麻醉管理:一例报告
Braz J Anesthesiol. 2023 Sep-Oct;73(5):695-698. doi: 10.1016/j.bjane.2021.02.045. Epub 2021 Apr 2.
2
Interaction of Analgesic Effects of Dezocine and Sufentanil for Relief of Postoperative Pain: A Pilot Study.地佐辛与舒芬太尼镇痛作用的相互影响:一项初步研究。
Drug Des Devel Ther. 2020 Nov 3;14:4717-4724. doi: 10.2147/DDDT.S270478. eCollection 2020.
3
Effects of dezocine, morphine and nalbuphine on electropain threshold, temperature pain threshold and cardiac function in rats with myocardial ischemia.地佐辛、吗啡和纳布啡对心肌缺血大鼠电痛阈、温度痛阈和心功能的影响。
Ann Palliat Med. 2020 Jul;9(4):1556-1563. doi: 10.21037/apm-19-460.
4
Postoperative analgesia using dezocine alleviates depressive symptoms after colorectal cancer surgery: A randomized, controlled, double-blind trial.地佐辛用于结直肠癌术后镇痛可缓解抑郁症状:一项随机、对照、双盲试验。
PLoS One. 2020 May 26;15(5):e0233412. doi: 10.1371/journal.pone.0233412. eCollection 2020.
5
Dezocine attenuates the remifentanil-induced postoperative hyperalgesia by inhibition of phosphorylation of CaMKⅡα.地佐辛通过抑制 CaMKⅡα 的磷酸化来减轻瑞芬太尼引起的术后痛觉过敏。
Eur J Pharmacol. 2020 Feb 15;869:172882. doi: 10.1016/j.ejphar.2019.172882. Epub 2019 Dec 19.
6
Comparison of the analgesic effects of dezocine, tramadol and butorphanol after cesarean section.剖宫产术后地佐辛、曲马多和布托啡诺镇痛效果的比较。
Pak J Pharm Sci. 2018 Sep;31(5(Special)):2191-2195.
7
Geographic Variations and Temporal Trends in Cesarean Delivery Rates in China, 2008-2014.中国 2008-2014 年剖宫产率的地域差异和时间趋势。
JAMA. 2017 Jan 3;317(1):69-76. doi: 10.1001/jama.2016.18663.
8
Paroxysmal Supraventricular Tachycardia: Pathophysiology, Diagnosis, and Management.阵发性室上性心动过速:病理生理学、诊断与管理
Crit Care Nurs Clin North Am. 2016 Sep;28(3):309-16. doi: 10.1016/j.cnc.2016.04.005. Epub 2016 Jun 7.
9
WHO Statement on caesarean section rates.世界卫生组织关于剖宫产率的声明。
Reprod Health Matters. 2015 May;23(45):149-50. doi: 10.1016/j.rhm.2015.07.007. Epub 2015 Jul 27.

剖宫产术中注射地佐辛后高血压危象合并阵发性室上性心动过速:一例报告

Hypertensive crisis merging with paroxysmal supraventricular tachycardia after dezocine injection during cesarean delivery: A case report.

作者信息

Huang Liping, Yan Xi, Yi Mingliang

机构信息

Department of Anesthesiology, Chengdu Fifth People's Hospital, Chengdu, China.

出版信息

SAGE Open Med Case Rep. 2023 Mar 21;11:2050313X231160980. doi: 10.1177/2050313X231160980. eCollection 2023.

DOI:10.1177/2050313X231160980
PMID:36968987
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10034336/
Abstract

Hypertensive crisis and paroxysmal supraventricular tachycardia are serious adverse reactions that can lead to fatal consequences. We reported a 28-year-old woman who underwent emergency cesarean section of her first fetus due to pelvic outlet stenosis and had a hypertensive crisis, merging with paroxysmal supraventricular tachycardia after dezocine was administrated during the procedure. Her symptoms returned to normal after esmolol and urapidil were administrated. In order to rule out hypertension crisis caused by other diseases, the anesthesiologist immediately accessed the thyroid function, myocardial enzymes, catecholamines, and arterial blood gas analysis of the patient. No obvious abnormality was found in all the test results. We infer the conclusion that the symptoms of this patient during the operation were most likely related to dezocine administration. This case highlights the need to pay attention to possible malignant adverse reactions while using dezocine during cesarean section, and we recommend the immediate use of α-receptor blockers and/or β-receptor blockers in situations like to avoid serious complications caused by supraventricular tachycardia.

摘要

高血压危象和阵发性室上性心动过速是严重的不良反应,可导致致命后果。我们报告了一名28岁女性,因骨盆出口狭窄接受了首次剖宫产手术,术中使用地佐辛后出现高血压危象,并合并阵发性室上性心动过速。给予艾司洛尔和乌拉地尔治疗后,她的症状恢复正常。为排除其他疾病引起的高血压危象,麻醉医生立即对患者进行了甲状腺功能、心肌酶、儿茶酚胺及动脉血气分析。所有检查结果均未发现明显异常。我们推断该患者术中症状很可能与使用地佐辛有关。该病例强调了剖宫产术中使用地佐辛时需注意可能出现的恶性不良反应,我们建议在类似情况下立即使用α受体阻滞剂和/或β受体阻滞剂,以避免室上性心动过速引起的严重并发症。