Wang Junwei, Zhang Cunming, Chen Baijun, Wu Qingqing
Department of Urology, Wenling Hospital Affiliated to Wenzhou Medical University (The First People's Hospital of Wenling), Taizhou, Zhejiang, China.
Department of Pathology, Wenling Hospital Affiliated to Wenzhou Medical University (The First People's Hospital of Wenling), Taizhou, Zhejiang, China.
Front Oncol. 2023 Mar 9;13:1094943. doi: 10.3389/fonc.2023.1094943. eCollection 2023.
Basal cell carcinoma of the prostate (BCCP) is a rare tumor with a total incidence of 140 cases to date. However, BCCP with squamous metaplasia has not been reported as of date. In this paper, we report the first case of BCCP with squamous metaplasia. The patient was hospitalized for progressive dyspareunia and had been treated for recurrent urinary retention four times in 5 years. Rectal examination showed that the prostate was medium in texture with no palpable nodules. The levels of total prostate specific antigen (tPSA), free prostate specific antigen (fPSA), and fPSA/tPSA (f/t) ratio were 1.29 ng/mL, 0.4 ng/mL, and 0.31, respectively. Ultrasound of the urinary tract showed that the prostate gland was 51 mm40 mm38 mm in size. We performed transurethral resection of the prostate. Histopathology confirmed the diagnosis of basal cell carcinoma with focal squamous differentiation, and immunohistochemical staining was positive for P63 and 34βE12. A laparoscopic radical prostatectomy was performed 45 days after the first surgery and the postoperative pathology showed a small amount of residual tumor with negative margins and no involvement of the seminal vesicles and vas deferens. The patient was followed up for 50 months and was doing well by the end of our study. We describe the clinical symptoms, pathological features, treatment, and prognosis of patients with BCCP with squamous metaplasia. The relevant published literature is also briefly reviewed.
前列腺基底细胞癌（BCCP）是一种罕见肿瘤，迄今为止总发病率为140例。然而，截至目前尚未有前列腺基底细胞癌伴鳞状化生的报道。在本文中，我们报告了首例前列腺基底细胞癌伴鳞状化生的病例。该患者因进行性性交困难入院，5年内曾4次因复发性尿潴留接受治疗。直肠指检显示前列腺质地中等，未触及结节。总前列腺特异性抗原（tPSA）、游离前列腺特异性抗原（fPSA）水平及fPSA/tPSA（f/t）比值分别为1.29 ng/mL、0.4 ng/mL和0.31。泌尿系统超声显示前列腺大小为51 mm×40 mm×38 mm。我们实施了经尿道前列腺切除术。组织病理学确诊为伴有局灶性鳞状分化的基底细胞癌，免疫组化染色P63和34βE12呈阳性。首次手术后45天进行了腹腔镜前列腺癌根治术，术后病理显示有少量残留肿瘤，切缘阴性，精囊和输精管未受累。对患者进行了50个月的随访，在我们研究结束时情况良好。我们描述了前列腺基底细胞癌伴鳞状化生患者的临床症状、病理特征、治疗及预后。并对相关已发表文献进行了简要回顾。
