Tsai L S
California State University, Fullerton.
Percept Mot Skills. 1987 Oct;65(2):580-2. doi: 10.2466/pms.1987.65.2.580.
30 adult male white rats were equally divided into control, scopolamine, and electroconvulsive shock groups to learn 20 successive reversal problems in an E-maze for water after 23 1/2 hr. of deprivation. The noncorrection method was used. After 1 mo. of preliminary training, each scopolamine animal received an intraperitoneal injection of 1 mgm of scopolamine hydrobromide per kgm of body weight while each in the shock group was given an ECS of 35 mA for .2 sec. at the end of every 10 daily trials. When a rat obtained 9 correct of 10 trials, the goal was switched to the opposite side of the maze. Controls were much superior to both experimental groups. While scopolamine animals experienced more detrimental effects initially, they caught up with the shock group and finally became superior. This shift is interpreted in terms of building tolerance to scopolamine and increasing anxiety to shock as effects of differential treatments accumulated.
30只成年雄性白鼠被平均分为对照组、东莨菪碱组和电惊厥休克组，在经过23.5小时禁水后，于E型迷宫中学习20个连续的逆向问题以获取水。采用非矫正方法。经过1个月的初步训练后，每只东莨菪碱组动物每千克体重腹腔注射1毫克氢溴酸东莨菪碱，而休克组的每只动物在每天10次试验结束时给予35毫安、持续0.2秒的电惊厥休克。当一只大鼠在10次试验中获得9次正确时，目标切换到迷宫的另一侧。对照组比两个实验组都优越得多。虽然东莨菪碱组动物最初受到的不利影响更大，但它们赶上了休克组，最终变得更优越。随着不同处理的效果积累，这种转变被解释为对东莨菪碱产生耐受性以及对休克的焦虑增加。
