Soffie M, Lamberty Y
Physiol Behav. 1987;40(2):263-5. doi: 10.1016/0031-9384(87)90218-6.
The effect of scopolamine (0.5 mg/kg) was determined in a brightness discrimination test (Y maze) motivated by electrical shocks (escape avoidance). Male adult Sprague Dawley rats were used. Results show that scopolamine impairs significantly the visual reversal without affecting the first brightness discrimination. The qualitative analysis reveals that the anticholinergic drug-induced deficit involves both perseveration, i.e. failure to suppress inappropriate response, and a tendency to adopt a position habit. A parallelism with hippocampal and frontal lobe damage symptoms is discussed and an interpretation in terms of disinhibition and incapacity to solve a more difficult problem is proposed.
在由电击驱动的亮度辨别测试（Y迷宫）中（逃避回避），测定了东莨菪碱（0.5毫克/千克）的效果。使用成年雄性Sprague Dawley大鼠。结果显示，东莨菪碱显著损害视觉反转，而不影响首次亮度辨别。定性分析表明，抗胆碱能药物引起的缺陷既涉及持续性，即无法抑制不适当反应，也涉及采取位置习惯的倾向。讨论了与海马体和额叶损伤症状的相似性，并提出了一种基于去抑制和无法解决更困难问题的解释。
