腺苷酰基-(2'-5')-硫代腺苷酰基-(2'-5')-腺苷及其5'-磷酸化衍生物的各个非对映异构体的制备。
Preparation of the individual diastereomers of adenylyl-(2'-5')-P-thioadenylyl-(2'-5')-adenosine and their 5'-phosphorylated derivatives.
作者信息
de Vroom E, Fidder A, Saris C P, van der Marel G A, van Boom J H
机构信息
Gorlaeus Laboratory, Leiden, The Netherlands.
出版信息
Nucleic Acids Res. 1987 Dec 10;15(23):9933-43. doi: 10.1093/nar/15.23.9933.
Abstract
The individual diastereomers of trimer A2'p5'A2'p(s)5'A, containing one phosphorothioate linkage, were prepared via a modified hydroxybenzotriazole phosphotriester approach. The 5'-phosphorylated derivatives of the latter compounds were obtained after phosphorylation with a 6-trifluoromethyl-1-benzotriazolyl activated phosphoromorpholidate.
摘要
通过改良的羟基苯并三唑磷酸三酯方法制备了含有一个硫代磷酸酯键的三聚体A2'p5'A2'p(s)5'A的各个非对映异构体。用6-三氟甲基-1-苯并三唑基活化的磷酰吗啉代物进行磷酸化反应后，得到了后一种化合物的5'-磷酸化衍生物。
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