DNA聚合酶的终止底物：合成与功能研究
Terminating substrates of DNA polymerases: synthesis and functional study.
作者信息
Dyatkina N B, Arzumanov A A
机构信息
Institute of Molecular Biology, USSR Academy of Sciences, Moscow.
出版信息
Nucleic Acids Symp Ser. 1987(18):117-20.
PMID:3697111
Abstract
In order to study the mechanisms of DNA biosynthesis a number of modified nucleoside - substrates of DNA polymerases was synthesized. The absence of hydroxyl at 3'-position of ribose results in terminating properties of DNA biosynthesis of these analogues. A single step synthesis of triphosphates and alpha-thiotriphosphates of natural and 3'-modified 2'-deoxynucleosides is described.
摘要
为了研究DNA生物合成的机制，合成了多种DNA聚合酶的修饰核苷底物。核糖3'-位羟基的缺失导致这些类似物的DNA生物合成具有终止特性。本文描述了天然及3'-修饰的2'-脱氧核苷三磷酸和α-硫代三磷酸的一步合成法。
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